NCB-0846 (Standard)
NCB-0846 (Standard) is the analytical standard of NCB-0846 (HY-100830). This product is intended for research and analytical applications. NCB-0846 is an orally active, selective inhibitor for Wnt, that inhibits Traf2- and Nck-interacting kinase (TNIK) with an IC50 of 21 nM. NCB-0846 blocks TGF-β signaling pathway by inhibiting SMAD2/3 phosphorylation and nuclear translocation.
Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.
- Pureté : 98%
- CAS No.: 1792999-26-8
- Formule: C21H21N5O2
- Masse moléculaire:375.42
-
Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Product Information
-
Chemical Information
- Pureté et documentation
-
Help & FAQs
-
HY-100830
NCB-0846TRAF2- and NCK-interacting Inhibitor -
HY-14428
ICG-001Apoptosis Inducer -
HY-13912
IWP-2Wnt Production Inhibitor -
HY-101085
SKL2001Wnt/β-catenin Pathway Agonist -
HY-109049
AdavivintWnt Pathway Inhibitor -
HY-19987
BML-284Wnt Signaling Activator -
HY-10182
LaduviglusibGSK-3 Inhibitor -
HY-101130
PNU-74654β-catenin/TCF Interaction Inhibitor -
HY-103705
iCRT3Wnt/β-Catenin Inhibitor -
HY-10182G
Laduviglusib (GMP)GSK-3α/β Inhibitor (GMP) -
HY-122816
HLY78Wnt/β-catenin Activator -
HY-12238
IWR-1Wnt Signaling Inhibitor
Product Information
Information
Application
The compound is the grade of analytical standard, which is the reference standard supplied assay. It is commonly used in qualitative, quantitative and methodological research experiments in HPLC, GC and MS.
Chemical Information
-
CAS No. 1792999-26-8
-
Masse moléculaire 375.42
-
Formule C21H21N5O2
-
SMILES
O[C@@H](CC1)CC[C@@H]1OC2=CC=CC(C=N3)=C2N=C3NC4=CC=C(N=CN5)C5=C4
-
Livraison
Room temperature in continental US; may vary elsewhere.
-
Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
[1]. Masuda M, et al. TNIK inhibition abrogates colorectal cancer stemness. Nat Commun. 2016 Aug 26;7:12586. [Content Brief]
[2]. Sugano T, et al., Pharmacological blockage of transforming growth factor-β signalling by a Traf2- and Nck-interacting kinase inhibitor, NCB-0846. Br J Cancer. 2021 Jan;124(1):228-236. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
NCB-0846 (Standard) Related Classifications
HY-100830R Related Classifications
Powered by Bioz