Cat. No.: HY-N2123

Neoliquiritin

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Neoliquiritin is a flavonoid and flavanone-derived cytotoxic agent with anticancer activity and neuroprotective effects. Neoliquiritin exhibits excellent tumor specificity, exerting a more pronounced killing effect on cancer cells compared with normal oral cells. Neoliquiritin also exerts neuroprotective effects by inhibiting ATP depletion and the elevation of caspase 3/7 activity. Widely present in the roots of Glycyrrhiza uralensis, Glycyrrhiza inflata and Glycyrrhiza glabra, Neoliquiritin can be applied to studies on human oral squamous cell carcinoma, leukemia, Parkinson's disease and other conditions.

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Pureté: 99.85%
CAS No.: 5088-75-5
Formule: C₂₁H₂₂O₉
Masse moléculaire:418.39

Stockage:

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Neoliquiritin Chemical Structure

CAS No.: 5088-75-5

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Publications (1)
Solvant et solubilité
- In Vitro
- In Vivo
Pureté et documentation
Références
Help & FAQs
Classifications
Bioz

Activité biologique

Description

IC₅₀ & Target

Caspase 3

Caspase-7

Voir tous les produits spécifiques à Isoform Caspase :

In Vitro

Neoliquiritin (48 h after 48 h initial cell seeding) shows moderate, cell-dependent cytotoxicity against HSC-2, HSC-3, HSC-4, HL-60 tumor cells and HGF, HPC, HPLF normal cells, with a tumor-specificity index of 0.264^[2].
Neoliquiritin (2.5-10 µg/mL; 24 h) significantly increases the viability of SH-SY5Y cells^[3].
Neoliquiritin (2.5-10 µg/mL; 2 h pre-treatment, followed by 24 h incubation with MPP⁺) significantly protects SH-SY5Y cells from MPP⁺-induced neurotoxicity, restoring cell viability to ~80% of control^[3].
Neoliquiritin (2.5 µg/mL; 2 h pre-treatment, followed by 24 h incubation with MPP⁺) significantly attenuates MPP⁺-induced elevation of caspase 3/7 activity in SH-SY5Y cells^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cytotoxicity Assay^[3]

Cell Line:

human neuroblastoma SH-SY5Y cells
Concentration:

2.5 µg/mL; 5 µg/mL; 10 µg/mL
Incubation Time:

24 h
Result:

Increased cell viability significantly relative to control at 2.5 µg/mL.
Increased cell viability significantly relative to control at 5 µg/mL.
Increased cell viability significantly relative to control at 10 µg/mL.

Cell Cytotoxicity Assay^[3]

Cell Line:

human neuroblastoma SH-SY5Y cells exposed to MPP+
Concentration:

2.5 µg/mL; 5 µg/mL; 10 µg/mL
Incubation Time:

2 h pre-treatment, followed by 24 h incubation with MPP+
Result:

Restored cell viability to ~80% of control relative to MPP⁺-treated cells at 2.5 µg/mL.
Restored cell viability to ~80% of control relative to MPP⁺-treated cells at 5 µg/mL.
Restored cell viability to ~80% of control relative to MPP⁺-treated cells at 10 µg/mL.

Apoptosis Analysis^[3]

Cell Line:

human neuroblastoma SH-SY5Y cells exposed to MPP+
Concentration:

2.5 µg/mL
Incubation Time:

2 h pre-treatment, followed by 24 h incubation with MPP+
Result:

Reduced caspase 3/7 activity to ~1.5-fold of control relative to MPP+-treated cells.

In Vivo

Licorice total flavonoids (LTF; containing 15.74% Neoliquiritin) (87.5-350 mg/kg; p.o.; daily; for 4 weeks) dose-dependently reduce MDA, cholesterol, TG levels and hepatic fat vacuole area in the liver of NAFLD mice, and improve the hepatic antioxidant status of mice with alcoholic liver disease^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Kunming mice with Non-alcoholic fatty liver disease (male, 8 weeks old, 20 g)^[1]
Dosage:

87.5 mg/kg; 175 mg/kg; 350 mg/kg
Administration:

p.o.; daily; 4 weeks
Result:

Reduced hepatic TG to 166.22 μmol/g, and reduced relative area of hepatic fat vacuoles by 73.68% at 87.5 mg/kg.
Reduced hepatic MDA to 2.12 nmol/g, hepatic cholesterol to 0.100 mmol/g, hepatic TG to 147.33 μmol/g, and reduced relative area of hepatic fat vacuoles by 79.53% at 175 mg/kg.
Reduced hepatic MDA to 1.99 nmol/g, hepatic cholesterol to 0.096 mmol/g, hepatic TG to 128.45 μmol/g, and reduced relative area of hepatic fat vacuoles by 85.14% at 350 mg/kg.

Chemical Information

CAS No. 5088-75-5
Appearance Solid
Masse moléculaire 418.39
Formule C₂₁H₂₂O₉
Color White to yellow
SMILES

O=C1C[C@@H](C2=CC=C(O)C=C2)OC3=CC(O[C@H]4[C@@H]([C@H]([C@@H]([C@@H](CO)O4)O)O)O)=CC=C13
Structure Classification
- Flavonoids
- Flavonones
- Phenols
- Monophenols
Initial Source
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Publications (1)

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Journal Impact Factor

Bioorg Med Chem

Identification of a novel Aurora B inhibitor using the AI-driven drug screening and docking-based traditional screening. [Abstract]

2025 Sep 27:131:118423. PMID: 41033076

Solvant et solubilité

In Vitro:

DMSO : 250 mg/mL (597.53 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

2.3901 mL

11.9506 mL

23.9011 mL

5 mM

0.4780 mL

2.3901 mL

4.7802 mL

10 mM

0.2390 mL

1.1951 mL

2.3901 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline

Solubility: ≥ 2.08 mg/mL (4.97 mM); Clear solution

This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)

Solubility: ≥ 2.08 mg/mL (4.97 mM); Clear solution

This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

%
DMSO +

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
%
+
+
%
Tween-80 + +
%
Saline +

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Working solution concentration: 0.22 mg/mL

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (278 KB)
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Gou S, et al. Hepatoprotective effect of total flavonoids from Glycyrrhiza uralensis Fisch in liver injury mice[J]. Natural product research, 2021, 35(24): 6083-6087.

[2]. Ohno H, et al. Evaluation of cytotoxiciy and tumor-specificity of licorice flavonoids based on chemical structure. Anticancer Res. 2013;33(8):3061-3068. [Content Brief]

[3]. Eltahir A O E, et al. Neuroprotective effects of Glycyrrhiza glabra total extract and isolated compounds[J]. Pharmaceuticals, 2024, 17(7): 852.

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	2.3901 mL	11.9506 mL	23.9011 mL	59.7529 mL
	5 mM	0.4780 mL	2.3901 mL	4.7802 mL	11.9506 mL
	10 mM	0.2390 mL	1.1951 mL	2.3901 mL	5.9753 mL
	15 mM	0.1593 mL	0.7967 mL	1.5934 mL	3.9835 mL
	20 mM	0.1195 mL	0.5975 mL	1.1951 mL	2.9876 mL
	25 mM	0.0956 mL	0.4780 mL	0.9560 mL	2.3901 mL
	30 mM	0.0797 mL	0.3984 mL	0.7967 mL	1.9918 mL
	40 mM	0.0598 mL	0.2988 mL	0.5975 mL	1.4938 mL
	50 mM	0.0478 mL	0.2390 mL	0.4780 mL	1.1951 mL
	60 mM	0.0398 mL	0.1992 mL	0.3984 mL	0.9959 mL
	80 mM	0.0299 mL	0.1494 mL	0.2988 mL	0.7469 mL
	100 mM	0.0239 mL	0.1195 mL	0.2390 mL	0.5975 mL

Keywords

Neoliquiritin

1 Cited Publications

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Neoliquiritin

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Publications Citing Use of MedChemExpress (MCE) Neoliquiritin

Voir tous les produits spécifiques à Isoform Caspase

Activité biologique

Chemical Information

Publications (1)

Solvant et solubilité

Pureté et documentation

Références

Help & FAQs

Complete Stock Solution Preparation Table

Neoliquiritin Related Classifications

HY-N2123 Related Classifications