5088-75-5
Chemical Structure
Neoliquiritin
- CAS No.: 5088-75-5
- Formula:C21H22O9
- Molecular Weight:418.39
IUPAC Name: (S)-2-(4-hydroxyphenyl)-7-(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)chroman-4-one
InChIKey: HJBUYKZTEBZNSH-ZRWXNEIDSA-N
SMILES: O=C1C[C@@H](C2=CC=C(O)C=C2)OC3=CC(O[C@H]4[C@@H]([C@H]([C@@H]([C@@H](CO)O4)O)O)O)=CC=C13
Biological Activity: Neoliquiritin is a flavonoid and flavanone-derived cytotoxic agent with anticancer activity and neuroprotective effects. Neoliquiritin exhibits excellent tumor specificity, exerting a more pronounced killing effect on cancer cells compared with normal oral cells. Neoliquiritin also exerts neuroprotective effects by inhibiting ATP depletion and the elevation of caspase 3/7 activity. Widely present in the roots of Glycyrrhiza uralensis, Glycyrrhiza inflata and Glycyrrhiza glabra, Neoliquiritin can be applied to studies on human oral squamous cell carcinoma, leukemia, Parkinson's disease and other conditions[1][2][3].
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Neoliquiritin | 99.85% | Neoliquiritin is a flavonoid and flavanone-derived cytotoxic agent with anticancer activity and neuroprotective effects. Neoliquiritin exhibits excellent tumor specificity, exerting a more pronounced killing effect on cancer cells compared with normal oral cells. Neoliquiritin also exerts neuroprotective effects by inhibiting ATP depletion and the elevation of caspase 3/7 activity. Widely present in the roots of Glycyrrhiza uralensis, Glycyrrhiza inflata and Glycyrrhiza glabra, Neoliquiritin can be applied to studies on human oral squamous cell carcinoma, leukemia, Parkinson's disease and other conditions. | ||||||||||||||||||||
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Neoliquiritin (Standard) | ≥98% | Neoliquiritin (Standard) is the analytical standard of Neoliquiritin. This product is intended for research and analytical applications. Neoliquiritin is isolated from Glycyrrhiza uralensis with an anti-inflammatory activity. | ||||||||||||||||||||
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- [1]. Gou S, et al. Hepatoprotective effect of total flavonoids from Glycyrrhiza uralensis Fisch in liver injury mice[J]. Natural product research, 2021, 35(24): 6083-6087.
- [2]. Ohno H, et al. Evaluation of cytotoxiciy and tumor-specificity of licorice flavonoids based on chemical structure. Anticancer Res. 2013;33(8):3061-3068. [Content Brief]
- [3]. Eltahir A O E, et al. Neuroprotective effects of Glycyrrhiza glabra total extract and isolated compounds[J]. Pharmaceuticals, 2024, 17(7): 852.
