PARP1-IN-20
PARP1-IN-20 (compound 19A10) is a potent inhibitor of PARP1, with the IC50 of 4.62 nM and has similar low PARP-Trapping effect compared with Veliparib (HY-10129), IC50 (MDA-MB-436) >100 μM.
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- CAS No.: 2659357-95-4
- Formule: C23H19BrN6O3S
- Masse moléculaire:539.40
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
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PARP1 4.62 nM (IC50) |
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Cell Line
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Type | Value | Description | References |
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| HUVEC | IC50 |
>100 μM
Compound: 19A10
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Inhibition of cell proliferation in HUVECs
Inhibition of cell proliferation in HUVECs
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[PMID: 38678823] |
| MCF7 | IC50 |
>100 μM
Compound: 19A10
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Inhibition of cell proliferation in human MCF7 cells
Inhibition of cell proliferation in human MCF7 cells
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[PMID: 38678823] |
| MDA-MB-436 | IC50 |
>100 μM
Compound: 19A10
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Inhibition of cell proliferation in human MDA-MB-436 cells assessed as PARP trapping effect
Inhibition of cell proliferation in human MDA-MB-436 cells assessed as PARP trapping effect
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[PMID: 38678823] |
Chemical Information
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CAS No. 2659357-95-4
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Masse moléculaire 539.40
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Formule C23H19BrN6O3S
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SMILES
O=C(N)C1=C2C(NC(C3=CC=C(C(N4CCN(C(C5=CSC(Br)=N5)=O)CC4)=O)C=C3)=N2)=CC=C1
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
PARP1-IN-20 Related Classifications
HY-161517 Related Classifications
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