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Cat. No.: HY-Y0683A

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Petrolatum (white)

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Petrolatum (white) is mainly composed of hydrocarbons, possesses strong water resistance and moisturizing properties, and is commonly used as a pharmaceutical excipient. Petrolatum (white) penetrates into stratum corneum cells, improves skin barrier function, repairs epidermal structure, and reduces transepidermal water loss and the risk of skin damage. Petrolatum (white) induces the expression of antimicrobial peptides, innate immune genes, filaggrin and loricrin. Petrolatum (white) is used in research on atopic dermatitis and post-operative skin infections.

Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.

Pureté: 99%
CAS No.: 8009-03-8

Stockage:

Pure form -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month

Petrolatum (white) Chemical Structure

CAS No.: 8009-03-8

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Activité biologique
- Description
- In Vitro
- In Vivo
Chemical Information
Solvant et solubilité
- In Vitro
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

In Vitro

Petrolatum (thin layer; once (acetone-perturbed skin), twice daily for 3 days (normal skin)) (white) penetrates all levels of the stratum corneum in both normal and acetone-perturbed post-mortem hairless mouse stratum corneum, localizing to intercellular spaces where it expands domains, separates bilayers, and forms distinct nonlamellar regions, without entering nucleated epidermal layers^[2].
Petrolatum (100%; 48 h occlusion, biopsy at 72 h) (white) upregulates the expression of antimicrobial peptides (S100A8, S100A9, DEFB4A, LCN2, PI3, CCL20) and innate immune genes, enhances the expression of filaggrin (FLG) and loricrin (LOR) and thickens the stratum corneum in human skin, and reduces the infiltration of CD3⁺/CD8⁺ T cells and CD1c⁺ dendritic cells in nonlesional atopic dermatitis skin^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Petrolatum (Thin layer; topical; single application, twice daily; 3 days) penetrates all levels of the murine stratum corneum via intercellular domains, dramatically reduces TEWL immediately after application to acetone-damaged skin, and does not impede endogenous barrier recovery^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 8009-03-8
Appearance <38°C Solid,>54°C Liquid
Color White to light yellow
SMILES

[Petrolatum (white)]
Livraison

Room temperature in continental US; may vary elsewhere.

Stockage

Pure form	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvant et solubilité

In Vitro:

DMSO : 200 mg/mL (Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (269 KB)
SDS (479 KB)
- English - EN (479 KB)
- Français - FR (479 KB)
- Deutsch - DE (479 KB)
- Norwegian - NO (479 KB)
- Español - ES (479 KB)
- Swedish - SV (479 KB)
- Italian - IT (479 KB)
- Korean - KR (479 KB)
- Portuguese - PT (479 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Elder DP, et al. Pharmaceutical excipients - quality, regulatory and biopharmaceutical considerations. Eur J Pharm Sci. 2016;87:88-99. [Content Brief]

[2]. Ghadially R, et al. Effects of petrolatum on stratum corneum structure and function[J]. Journal of the American Academy of Dermatology, 1992, 26(3): 387-396.

[3]. Czarnowicki T, et al. Petrolatum: Barrier repair and antimicrobial responses underlying this "inert" moisturizer. J Allergy Clin Immunol. 2016;137(4):1091-1102.e7. [Content Brief]

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

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Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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