Tasisulam sodium
Based on 1 publication(s) in Google Scholar
Tasisulam is a anticancer agent and induces apoptosis via the intrinsic pathway, resulting in cytochrome c release and caspase-dependent cell death. Tasisulam inhibits mitotic progression and induces vascular normalization.
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- CAS No.: 519055-63-1
- Formule: C11H5BrCl2NNaO3S2
- Masse moléculaire:437.09
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Activité biologique
Tasisulam sodium (200 nM-200 μM; 48 hours) induces an antiproliferative response across a wide range of tumor histologies with EC50s of 10 μM and 25 μM for Calu-6 and A-375 cell lines, respectively[1].
Tasisulam sodium (25, 50 μM; 72 hours) induces a concentration-dependent increase in 4N DNA and G2-M accumulation[1].
Tasisulam sodium (200 nM-200 μM; 48 hours) induces apoptosis in a broad range of in vitro cancer cell models[1].
Tasisulam sodium also blocks VEGF, epidermal growth factor, and fibroblast growth factor-induced endothelial cell cord formation[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Calu-6 non-small cell lung carcinoma and A-375 melanoma models
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Concentration:200 nM-200 μM
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Incubation Time:48 hours
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Result:Induced an antiproliferative response across a wide range of tumor histologies with EC50s is 10 μM and 25 μM, respectively.
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Cell Line:Calu-6 and A-375 cell lines
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Concentration:25, 50 μM
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Incubation Time:72 hours
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Result:Induced a concentration-dependent increase in 4N DNA and G2-M accumulation.
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Cell Line:Calu-6 non-small cell lung carcinoma and A-375 melanoma models
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Concentration:200 nM-200 μM
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Incubation Time:48 hours
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Result:Induced apoptosis in a broad range of in vitro cancer cell models.
Chemical Information
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CAS No. 519055-63-1
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Masse moléculaire 437.09
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Formule C11H5BrCl2NNaO3S2
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SMILES
O=C(N([Na])S(=O)(C1=CC=C(Br)S1)=O)C2=CC=C(Cl)C=C2Cl
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Synonyms
LY 573636 sodium
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (1)
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Journal Impact Factor
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Most Recent
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Anal Chem
Exposome-Scale Investigation of Cl-/Br-Containing Chemicals Using High-Resolution Mass Spectrometry, Multistage Machine Learning, and Cloud Computing. [Abstract]2025 Jun 3;97(21):11099-11109. PMID: 40401576
Pureté et documentation
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Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Tasisulam sodium Related Classifications
HY-14804A Related Classifications
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