Thiocoumarin
Thiocoumarin is a carbonic anhydrase (CA) inhibitor, with Ki values of 0.047 μM, 0.042 μM, and 0.1 μM against hCA IX, mCA XIII, and hCA I, respectively; its Ki values against hCA IV, mCA XV, hCA II, hCA VA, hCA VB, hCA VI, hCA VII, hCA XII, and hCA XIV are 4.1, 4.8, 6.2, 8.4, 7.5, 8.8, 7.3, 8.7, and 7.4 μM, respectively. As a photocage molecule, Thiocoumarin undergoes photolysis upon illumination to release the caged molecule, and it exhibits red-shifted absorption properties and rapid photolysis kinetics. Thiocoumarin can be used in cancer-related research.
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- CAS No.: 3986-98-9
- Formule: C9H6OS
- Masse moléculaire:162.21
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
Thiocoumarin-caged ATP is rapidly and cleanly uncaged to release ATP upon irradiation with 490 nm light (full release within 4 min at all tested intensities) or 400 nm light (full release within 30 s at 50% intensity) at a concentration of 1 mM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 3986-98-9
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Masse moléculaire 162.21
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Formule C9H6OS
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SMILES
S=C1OC2=C(C=C1)C=CC=C2
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
[1]. Ma J, et al. Thiocoumarin Caged Nucleotides: Synthetic Access and Their Photophysical Properties. Molecules (Basel, Switzerland). 2020 Nov 15;25(22):5325. [Content Brief]
[2]. Maresca A, et al. Deciphering the mechanism of carbonic anhydrase inhibition with coumarins and thiocoumarins. Journal of medicinal chemistry. 2010 Jan 14;53(1):335-44. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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