Thyroglobulin
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Thyroglobulin is a 660 kDa, dimeric glycoprotein produced by the follicular cells of the thyroid and used entirely within the thyroid gland. Thyroglobulin acts as a substrate for the synthesis of the thyroid hormones thyroxine (T4) and triiodothyronine (T3), as well as the storage of the inactive forms of thyroid hormone and iodine within the follicular lumen of a thyroid follicle. Thyroglobulin activates Akt kinase activity in FRTL-5 thyroid cell.
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- Pureté: 93%
- CAS No.: 9010-34-8
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
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Solvant et solubilité
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
others
Thyroglobulin (0-10 mg/mL; 12 h to 5 days) stimulates cell growth and DNA synthesis in quiescent FRTL-5 thyroid cells, with maximal activity at 5 mg/mL and reduced activity at higher concentrations[1].
Thyroglobulin (5 mg/mL; 12 h) does not increase cAMP levels in FRTL-5 thyroid cells[1].
Thyroglobulin (5 mg/mL; 30-180 min) activates Akt kinase activity in FRTL-5 thyroid cells within 30 min[1].
Thyroglobulin (0-10 mg/mL) suppresses TPO promoter activity in FRTL-5 thyroid cells in vitro in a concentration-dependent manner[1].
Thyroglobulin (0-10 mg/mL; 24 h) modulates PDS mRNA expression in FRTL-5 thyroid cells, with maximal expression at 5 mg/mL and reduced expression at higher concentrations[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:rat FRTL-5 thyroid cells
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Concentration:5 mg/mL (cell counting; maximal ³H-TdR incorporation); 0-10 mg/mL (³H-TdR concentration dependence)
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Incubation Time:up to 5 days (cell counting); 12 h (³H-TdR incorporation)
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Result:Increased cell number to levels comparable to complete medium (TSH + insulin + 5% serum) over 5 days using 5 mg/mL. Maximized ³H-TdR incorporation at 5 mg/mL, and reduced incorporation at 10 mg/mL.
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS No. 9010-34-8
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Appearance Solid
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Color Light brown to brown
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SMILES
[Thyroglobulin]
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Synonyms
Thyroglobulin from bovine
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Solvant et solubilité
H2O : 50 mg/mL (Need ultrasonic)
Pureté et documentation
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Fiche technique (268 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Instruction de manipulation (2659 KB)
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Thyroglobulin Related Classifications
HY-107903 Related Classifications
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