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Cat. No.: HY-158312A

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UH15-38 TFA

1 Cited Publications

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UH15-38 TFA is a potent RIPK3 inhibitor with an IC₅₀ value of 20 nM. UH15-38 TFA blocks IAV (influenza A virus)-activated necroptosis. UH15-38 TFA dampens IAV-induced lung injury.

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Formule: C₂₈H₂₈F₃N₅O₄
Masse moléculaire:555.55

Stockage:

-20°C, sealed storage, away from moisture and light

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

UH15-38 TFA Chemical Structure

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Publications (1)
Pureté et documentation
Références
Calculators
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Activité biologique

Description

UH15-38 TFA is a potent RIPK3 inhibitor with an IC₅₀ value of 20 nM. UH15-38 TFA blocks IAV (influenza A virus)-activated necroptosis. UH15-38 TFA dampens IAV-induced lung injury^[1].

IC₅₀ & Target^[1]

RIPK3

20 nM (IC₅₀)

Voir tous les produits spécifiques à Isoform RIP kinase :

In Vitro

UH15-38 (0-1000 nM; 12 h) TFA decreases the expression of pMLKL induced by TCZ in a dose-dependent manner^[1].
UH15-38 (0-1000 nM) TFA protects type I alveolar epithelial cells from canonical TNF-induced necroptosis and prevents IAV-induced necroptosis^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[1]

Cell Line:

Mouse embryonic fibroblasts
Concentration:

0, 25, 50, 100, 250, 500, 750, 1000 nM
Incubation Time:

12 h
Result:

Decreased the expression of pMLKL induced by TCZ (mouse TNF (100 ng/ml), cycloheximide (250 ng/ml) and zVAD (50 μM)) in a time dependent manner.

In Vivo

UH15-38 (30 mg/kg; i.p.; daily for 4 days) TFA inhibits IAV (Influenza A virus)-induced lung injury in mice^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

C57Bl/6 mice (lethal dose of PR8 (6,000 × EID50))^[1]
Dosage:

30 mg/kg
Administration:

I.p.; once daily for 4 days; starting 24 h after infection
Result:

Markedly reduced numbers of pMLKL+ necroptotic cells, decreased in diffuse alveolar damage and the formation of hyaline membranes, reduced the extent of fibrotic lung damage, displayed significantly lower levels of the pro-fibrotic mediators (IL-1β, IL-6, IL-18, IL-17 and CCL5).

Chemical Information

Appearance Solid
Masse moléculaire 555.55
Formule C₂₈H₂₈F₃N₅O₄
SMILES

CN1CCN(CC1)C2=CC(NC3=NC=C4C=C(C(N(C4=C3)C)=O)C5=CC(O)=CC=C5)=CC=C2.O=C(C(F)(F)F)O
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

-20°C, sealed storage, away from moisture and light

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Publications (1)

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Transbound Emerg Dis

Activation of ZBP1/RIPK3/MLKL-Dependent Necroptosis by Pseudorabies Virus Restricts Viral Infection in BV2 Microglia Cells. [Abstract]

2025 Oct 7:2025:8510846. PMID: 41098523

Pureté et documentation

Instruction de manipulation (2659 KB)

Références

[1]. Gautam A, et al. Necroptosis blockade prevents lung injury in severe influenza. Nature. 2024 Apr;628(8009):835-843. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

UH15-38 TFA

1 Cited Publications

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Activité biologique
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Publications (1)
Pureté et documentation
Références

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UH15-38 TFA

Publications Citing Use of MedChemExpress (MCE) UH15-38 TFA

Voir tous les produits spécifiques à Isoform RIP kinase

Activité biologique

Chemical Information

Publications (1)

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UH15-38 TFA Related Classifications

HY-158312A Related Classifications