1000277-08-6
Chemical Structure
MGB-BP-3
- CAS No.: 1000277-08-6
- Formula:C36H37N7O4
- Molecular Weight:631.72
IUPAC Name: (E)-1-methyl-4-(1-methyl-4-(4-(2-(quinolin-3-yl)vinyl)benzamido)-1H-pyrrole-2-carboxamido)-N-(2-morpholinoethyl)-1H-pyrrole-2-carboxamide
InChIKey: OEKXCVYZBVOWBR-BQYQJAHWSA-N
SMILES: O=C(C1=CC(NC(C2=CC=C(/C=C/C3=CC4=CC=CC=C4N=C3)C=C2)=O)=CN1C)NC5=CN(C)C(C(NCCN6CCOCC6)=O)=C5
Biological Activity: MGB-BP-3 is an orally aective Gram-positive bactericide and DNA-binding agent. MGB-BP-3 blocks transcription initiation by binding to AT-rich bacterial DNA regions, and interferes with the functions of DNA gyrase and topoisomerase IV, but does not stabilize cleavage complexes or induce the SOS response. MGB-BP-3 induces energy depletion in *Staphylococcus aureus* and inhibits spore formation in *Clostridioides difficile*, exhibiting intrinsic resistance resilience. MGB-BP-3 can be used in the research of *Clostridioides difficile*-associated diseases[1][2][3].
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MGB-BP-3 | 99.85% | MGB-BP-3 is an orally aective Gram-positive bactericide and DNA-binding agent. MGB-BP-3 blocks transcription initiation by binding to AT-rich bacterial DNA regions, and interferes with the functions of DNA gyrase and topoisomerase IV, but does not stabilize cleavage complexes or induce the SOS response. MGB-BP-3 induces energy depletion in *Staphylococcus aureus* and inhibits spore formation in *Clostridioides difficile*, exhibiting intrinsic resistance resilience. MGB-BP-3 can be used in the research of *Clostridioides difficile*-associated diseases. | ||||||||||||||||||||
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MGB-BP-3 (Standard) | ≥98% | Sinapine (thiocyanate) (Standard) is the analytical standard of Sinapine (thiocyanate). This product is intended for research and analytical applications. Sinapine thiocyanate is an alkaloid isolated from seeds of the cruciferous species. Sinapine thiocyanate exhibits anti-inflammatory, anti-oxidant, anti-tumor, anti-angiogenic and radio-protective effects. Sinapine thiocyanate is also an acetylcholinesterase (AChE) inhibitor and can be used for the research of Alzheimer’s disease, ataxia, myasthenia gravis, and Parkinson’s disease. | ||||||||||||||||||||
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- [1]. Hind C, et al. Insights into the Spectrum of Activity and Mechanism of Action of MGB-BP-3. ACS infectious diseases. 2022 Dec 09;8(12):2552-2563. [Content Brief]
- [2]. Suckling CJ, et al. Multitargeted anti-infective drugs: resilience to resistance in the antimicrobial resistance era. Future drug discovery. 2022 Apr;4(1):FDD73. [Content Brief]
- [3]. Alshrari A S, et al. The urgent threat of Clostridioides difficile infection: A glimpse of the drugs of the future, with related patents and prospects[J]. Biomedicines, 2023, 11(2): 426.
Keywords
