1192750-33-6
Chemical Structure
PE154
- CAS No.: 1192750-33-6
- Formula:C35H35N5O4
- Molecular Weight:589.68
IUPAC Name: (E)-2-(4-(((7-(diethylamino)-2,4-dioxochroman-3-ylidene)methyl)amino)phenyl)-N'-(1,2,3,4-tetrahydroacridin-9-yl)acetohydrazide
InChIKey: CYZIIGRHLSZNAV-SGWCAAJKSA-N
SMILES: O=C(NNC1=C(CCCC2)C2=NC3=CC=CC=C31)CC4=CC=C(N/C=C(C(C5=CC=C(N(CC)CC)C=C5O6)=O)/C6=O)C=C4
Biological Activity: PE154 is a fluorescent probe that binds to Aβ plaques, as well as a potent fluorescent inhibitor of AChE and BChE, with an IC50 of 280 pM against hAChE and 16 nM against hBChE. PE154 is applicable for histochemical detection of Aβ plaques in mouse and human brain tissues. PE154 can be used in research related to Alzheimer's disease[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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PE154 | 99.01% | PE154 is a fluorescent probe that binds to Aβ plaques, as well as a potent fluorescent inhibitor of AChE and BChE, with an IC50 of 280 pM against hAChE and 16 nM against hBChE. PE154 is applicable for histochemical detection of Aβ plaques in mouse and human brain tissues. PE154 can be used in research related to Alzheimer's disease. | ||||||||||||||||||||
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- [1]. Brambilla D, et al. Nanotechnologies for Alzheimer's disease: diagnosis, therapy, and safety issues. Nanomedicine : nanotechnology, biology, and medicine. 2011 Oct;7(5):521-40. [Content Brief]
- [2]. Härtig W, et al. In vivo labelling of hippocampal beta-amyloid in triple-transgenic mice with a fluorescent acetylcholinesterase inhibitor released from nanoparticles. The European journal of neuroscience. 2010 Jan;31(1):99-109. [Content Brief]
- [3]. Elsinghorst PW, et al. A gorge-spanning, high-affinity cholinesterase inhibitor to explore beta-amyloid plaques. Organic & biomolecular chemistry. 2009 Oct 07;7(19):3940-6. [Content Brief]
Keywords
