119963-50-7
119963-50-7
Chemical Structure
1,2-Didehydrotanshinone IIA
- CAS No.: 119963-50-7
- Formula:C19H16O3
- Molecular Weight:292.33
InChIKey: PURTYNPVRFEUEN-UHFFFAOYSA-N
SMILES: O=C1C(C2=C(C3=C1C(C=CCC4(C)C)=C4C=C3)OC=C2C)=O
Biological Activity: 1,2-Didehydrotanshinone IIA is a moderate AChE and BChE inhibitor, with an IC50 value of 5.98 μM for BChE[1]. 1,2-Didehydrotanshinone IIA is a IDO inhibitor, with an IC50 value of 4.68 µM μM[2].
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1,2-Didehydrotanshinone IIA | 1,2-Didehydrotanshinone IIA is a moderate AChE and BChE inhibitor, with an IC50 value of 5.98 μM for BChE. 1,2-Didehydrotanshinone IIA is a IDO inhibitor, with an IC50 value of 4.68 µM μM. | |||||||||||||||||||||
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References
- [1]. F Sezer Senol, et al. Selective in vitro and in silico butyrylcholinesterase inhibitory activity of diterpenes and rosmarinic acid isolated from Perovskia atriplicifolia Benth. and Salvia glutinosa L. Phytochemistry. 2017 Jan:133:33-44. [Content Brief]
- [2]. Zhang H, Liu W, Liu Z, et al. Discovery of indoleamine 2,3-dioxygenase inhibitors using machine learning based virtual screening. Medchemcomm. 2018;9(6):937-945. [Content Brief]
