1332075-41-8
1332075-41-8
Chemical Structure
H-HoArg-OH-d4
Synonym(s): L-Homoarginine-d4
- CAS No.: 1332075-41-8
- Formula:C7H12D4N4O2
- Molecular Weight:192.25
IUPAC Name: 2-amino-3-hydroxybenzoic-4,5,6-d3 acid
InChIKey: QUOGESRFPZDMMT-OZDFLOAESA-N
SMILES: OC([C@@H](N)CC([2H])([2H])C([2H])([2H])CNC(N)=N)=O
Biological Activity: H-HoArg-OH-d4 (L-Homoarginine-d4) is the d4-labeled H-HoArg-OH (HY-W008385). H-HoArg-OH (L-Homoarginine) is an orally active endogenous non-protein amino acid. H-HoArg-OH acts as a weak alternative substrate for NOS and interferes with NO production, selectively inhibits tissue-nonspecific alkaline phosphatase (TNAP), and suppresses the uptake of arginine by y+-type transporters (system y+). H-HoArg-OH increases tissue hArg concentrations in vivo, regulates amino acid homeostasis, and improves renal function and pathological features of diabetic nephropathy. H-HoArg-OH can be used in studies related to diabetes and cardiomyopathy[1][2][3][4][5].
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H-HoArg-OH-d4 | H-HoArg-OH-d4 (L-Homoarginine-d4) is the d4-labeled H-HoArg-OH (HY-W008385). H-HoArg-OH (L-Homoarginine) is an orally active endogenous non-protein amino acid. H-HoArg-OH acts as a weak alternative substrate for NOS and interferes with NO production, selectively inhibits tissue-nonspecific alkaline phosphatase (TNAP), and suppresses the uptake of arginine by y+-type transporters (system y+). H-HoArg-OH increases tissue hArg concentrations in vivo, regulates amino acid homeostasis, and improves renal function and pathological features of diabetic nephropathy. H-HoArg-OH can be used in studies related to diabetes and cardiomyopathy. | |||||||||||||||||||||
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H-HomoArg-OH hydrochloride (Standard) | ≥98% | H-HomoArg-OH hydrochloride (Standard) is the analytical standard of H-HomoArg-OH hydrochloride (HY-W012340). This product is intended for research and analytical applications. H-HomoArg-OH hydrochloride (L-Homoarginine hydrochloride) is an orally active endogenous non-protein amino acid. H-HomoArg-OH hydrochloride acts as a weak alternative substrate for NOS and interferes with NO production, selectively inhibits tissue-nonspecific alkaline phosphatase (TNAP), and suppresses the uptake of arginine by y+-type transporters (system y+). H-HomoArg-OH hydrochloride increases tissue hArg concentrations in vivo, regulates amino acid homeostasis, and improves renal function and pathological features of diabetic nephropathy. H-HomoArg-OH hydrochloride can be used in studies related to diabetes and cardiomyopathy. | ||||||||||||||||||||
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H-HomoArg-OH-13C7,15N4 hydrochloride | 98.0% | H-HomoArg-OH-13C7,15N4 hydrochloride (L-Homoarginine-13C7,15N4 hydrochloride) is the 15N, 13C-labeled H-HomoArg-OH (hydrochloride) (HY-W012340). H-HomoArg-OH hydrochloride (L-Homoarginine hydrochloride) is an orally active endogenous non-protein amino acid. H-HomoArg-OH hydrochloride acts as a weak alternative substrate for NOS and interferes with NO production, selectively inhibits tissue-nonspecific alkaline phosphatase (TNAP), and suppresses the uptake of arginine by y+-type transporters (system y+). H-HomoArg-OH hydrochloride increases tissue hArg concentrations in vivo, regulates amino acid homeostasis, and improves renal function and pathological features of diabetic nephropathy. H-HomoArg-OH hydrochloride can be used in studies related to diabetes and cardiomyopathy. | ||||||||||||||||||||
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H-HomoArg-OH hydrochloride | 98.0% | H-HomoArg-OH hydrochloride (L-Homoarginine hydrochloride) is an orally active endogenous non-protein amino acid. H-HomoArg-OH hydrochloride acts as a weak alternative substrate for NOS and interferes with NO production, selectively inhibits tissue-nonspecific alkaline phosphatase (TNAP), and suppresses the uptake of arginine by y+-type transporters (system y+). H-HomoArg-OH hydrochloride increases tissue hArg concentrations in vivo, regulates amino acid homeostasis, and improves renal function and pathological features of diabetic nephropathy. H-HomoArg-OH hydrochloride can be used in studies related to diabetes and cardiomyopathy. | ||||||||||||||||||||
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References
- [1]. Hira T, et al. L-homoarginine suppresses exocrine pancreas in rats. Amino acids. 2003 Jun;24(4):389-96.
- [2]. Wetzel MD, et al. l-Homoarginine supplementation prevents diabetic kidney damage. Physiological reports. 2019 Sep;7(18):e14235.
- [3]. Hou Y, et al. Whole-body synthesis of L-homoarginine in pigs and rats supplemented with L-arginine. Amino acids. 2016 Apr;48(4):993-1001.
- [4]. Fishman W, et al. L-homoarginine; an inhibitor of serum "bone and liver" alkaline phosphatase. Clin Chim Acta. 1970 Aug;29(2):339-41. [Content Brief]
- [5]. Tsikas D, et al. Pilot Study on Acute Effects of Pharmacological Intraperitoneal L-Homoarginine on Homeostasis of Lysine and Other Amino Acids in a Rat Model of Isoprenaline-Induced Takotsubo Cardiomyopathy. International journal of molecular sciences. 2022 Apr 25;23(9):4734.
