140694-43-5
Chemical Structure
TY 11223
- CAS No.: 140694-43-5
- Formula:C24H34O5
- Molecular Weight:402.52
InChIKey: XTIXMPSOPHPWLE-VNXMGFANSA-N
SMILES: CCC#CCC(C)(C)[C@H](O)C#C[C@@H]1[C@]2([H])[C@@](C[C@H]1O)([H])C=C(CC2)CCOCC(O)=O
Biological Activity: TY 11223 is an orally active, long-acting platelet aggregation inhibitor belonging to prostaglandin analogs. TY-11223 inhibits ADP (HY-W010918)- and Collagen-induced aggregation of washed rabbit platelets, with IC50 values of 2.6 nM and 8.6 nM, respectively. TY 11223 exerts hypotensive effects and alleviates ethanol-induced gastric ulcers, with an ED50 of 15.3 μg/kg when administered orally 30 minutes before ethanol exposure. TY 11223 can be used in research related to cardiovascular diseases and gastric ulcers[1][2].
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TY 11223 | TY 11223 is an orally active, long-acting platelet aggregation inhibitor belonging to prostaglandin analogs. TY-11223 inhibits ADP (HY-W010918)- and Collagen-induced aggregation of washed rabbit platelets, with IC50 values of 2.6 nM and 8.6 nM, respectively. TY 11223 exerts hypotensive effects and alleviates ethanol-induced gastric ulcers, with an ED50 of 15.3 μg/kg when administered orally 30 minutes before ethanol exposure. TY 11223 can be used in research related to cardiovascular diseases and gastric ulcers. | |||||||||||||||||||||
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References
- [1]. Shibasaki M, et al. A novel homoisocarbacyclin analog with potent and long-lasting activity. Chemical & pharmaceutical bulletin. 1992 Jan;40(1):279-81. [Content Brief]
- [2]. Narita S, et al. Syntheses and biological activities of chemically stable prostacyclin mimics with cis-bicyclo[4.3.0]nonene ring system: the novel homoisocarbacyclin analogues. Bioorg Med Chem. 1993 Aug;1(2):77-118. [Content Brief]
