A novel homoisocarbacyclin analog with potent and long-lasting activity

  • Chem Pharm Bull (Tokyo). 1992 Jan;40(1):279-81. doi: 10.1248/cpb.40.279.
M Shibasaki  1 ,  A Takahashi ,  T Aoki ,  H Sato ,  S Yamada ,  M Kudo ,  K Kogi ,  S Narita
Affiliations
  • 1. Faculty of Pharmaceutical Sciences, Hokkaido University, Sapporo, Japan.
PMID: 1576688 DOI: 10.1248/cpb.40.279
Abstract

A synthesis of a novel and chemically stable homoisocarbacyclin analog, TY-11223 (3), has been accomplished. The analog (3), given intravenously or orally, showed potent and long-lasting activities in inhibiting platelet aggregation and, in addition, a good selectivity in biological activities.

Products