Syntheses and biological activities of chemically stable prostacyclin mimics with cis-bicyclo[4.3.0]nonene ring system: the novel homoisocarbacyclin analogues

  • Bioorg Med Chem. 1993 Aug;1(2):77-118. doi: 10.1016/s0968-0896(00)82108-2.
S Narita  1 ,  A Takahashi ,  T Aoki ,  H Sato ,  S Satoh ,  S Yamada ,  M Kudo ,  T Yamaguchi ,  K Kogi ,  M Shibasaki
Affiliations
  • 1. Fukushima Research Laboratories, TOA EIYO Ltd., Japan.
PMID: 8081847 DOI: 10.1016/s0968-0896(00)82108-2
Abstract

The synthetic studies concerning a series of homoisocarbacyclin analogues, which are homologous compounds of isocarbacyclin, with cis-bicyclo[4.3.0]non-2-ene or cis-bicyclo[4.3.0]non-3-ene as a nucleus have been carried out. The general synthetic methods of homoisocarbacyclin analogues have been accomplished starting with the versatile Corey lactone. Among the analogues synthesized in the present studies, a promising compound (TY-11223) exhibiting a good selectivity in biological actions was found to be studied further.

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