1883548-90-0
Chemical Structure
Donepezil-d5 hydrochloride
Synonym(s): E2020-d5
- CAS No.: 1883548-90-0
- Formula:C24H25D5ClNO3
- Molecular Weight:420.98
IUPAC Name: 5,6-dimethoxy-2-((1-((phenyl-d5)methyl)piperidin-4-yl)methyl)-2,3-dihydro-1H-inden-1-one hydrochloride
InChIKey: XWAIAVWHZJNZQQ-BQAHAFBHSA-N
SMILES: O=C1C(CC2=CC(OC)=C(C=C21)OC)CC3CCN(CC3)CC4=C(C([2H])=C(C([2H])=C4[2H])[2H])[2H].Cl
Biological Activity: Donepezil-d5 (hydrochloride) is deuterium labeled Donepezil (Hydrochloride). Donepezil Hydrochloride (E2020) is a reversible, selective AChE inhibitor with an IC50 of 6.7 nM for AChE activity. Donepezil shows high selectivity for AChE over BuChE[1]. Donepezil exhibits neuroprotective effect on Aβ42 neurotoxicity[2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Donepezil-d5 hydrochloride | 99.27% | Donepezil-d5 (hydrochloride) is deuterium labeled Donepezil (Hydrochloride). Donepezil Hydrochloride (E2020) is a reversible, selective AChE inhibitor with an IC50 of 6.7 nM for AChE activity. Donepezil shows high selectivity for AChE over BuChE. Donepezil exhibits neuroprotective effect on Aβ42 neurotoxicity. | ||||||||||||||||||||
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Donepezil Hydrochloride (Standard) | ≥98% | Donepezil (Hydrochloride) (Standard) is the analytical standard of Donepezil (Hydrochloride). This product is intended for research and analytical applications. Donepezil Hydrochloride (E2020) is a reversible, selective AChE inhibitor with an IC50 of 6.7 nM for AChE activity. Donepezil shows high selectivity for AChE over BuChE. Donepezil exhibits neuroprotective effect on Aβ42 neurotoxicity. | ||||||||||||||||||||
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Donepezil-d4 hydrochloride | 99.96% | Donepezil-d4 (hydrochloride) is the deuterium labeled Donepezil hydrochloride. Donepezil Hydrochloride (E2020) is a reversible, selective AChE inhibitor with an IC50 of 6.7 nM for AChE activity. Donepezil shows high selectivity for AChE over BuChE. Donepezil exhibits neuroprotective effect on Aβ42 neurotoxicity. | ||||||||||||||||||||
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Donepezil-d7 hydrochloride | 99.0% | Donepezil-d7 (hydrochloride) is the deuterium labeled Donepezil. Donepezil (E2020 free base) is a specific and potent AChE inhibitor with IC50s of 8.12 nM and 11.6 nM for bovine AChE and human AChE, respectively. | ||||||||||||||||||||
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Donepezil Hydrochloride | 99.92% | Donepezil Hydrochloride (E2020) is a reversible, selective AChE inhibitor with an IC50 of 6.7 nM for AChE activity. Donepezil shows high selectivity for AChE over BuChE. Donepezil exhibits neuroprotective effect on Aβ42 neurotoxicity. | ||||||||||||||||||||
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- [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]
- [2]. H Ogura, et al. Comparison of inhibitory activities of donepezil and other cholinesterase inhibitors on acetylcholinesterase and butyrylcholinesterase in vitro. Methods Find Exp Clin Pharmacol. 2000 Oct;22(8):609-13. [Content Brief]
