24808-04-6
Chemical Structure
(-)-Epiafzelechin
- CAS No.: 24808-04-6
- Formula:C15H14O5
- Molecular Weight:274.27
IUPAC Name: (2R,3R)-2-(4-hydroxyphenyl)chromane-3,5,7-triol
InChIKey: RSYUFYQTACJFML-UKRRQHHQSA-N
SMILES: O[C@H]1[C@@H](C2=CC=C(O)C=C2)OC3=CC(O)=CC(O)=C3C1
Biological Activity: (−)-Epiafzelechin is a COX-1 inhibitor with an IC50 of approximately 15 μM against COX-1 activity. (−)-Epiafzelechin also exhibits DPPH free radical scavenging activity, with an EC50 of 20.9 μM. (−)-Epiafzelechin promotes osteoblast differentiation by increasing ALP activity, ECM collagen content and Runx2 expression, while reducing the growth of osteoclast precursors and RANKL-induced TRAP activity, thereby regulating the bone remodeling process. (−)-Epiafzelechin alleviates ovariectomy-induced bone loss. (−)-Epiafzelechin can be used in studies related to bone remodeling, postmenopausal osteoporosis, inflammatory responses and oxidative stress[1][2][3][4][5].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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(-)-Epiafzelechin | 99.87% | (−)-Epiafzelechin is a COX-1 inhibitor with an IC50 of approximately 15 μM against COX-1 activity. (−)-Epiafzelechin also exhibits DPPH free radical scavenging activity, with an EC50 of 20.9 μM. (−)-Epiafzelechin promotes osteoblast differentiation by increasing ALP activity, ECM collagen content and Runx2 expression, while reducing the growth of osteoclast precursors and RANKL-induced TRAP activity, thereby regulating the bone remodeling process. (−)-Epiafzelechin alleviates ovariectomy-induced bone loss. (−)-Epiafzelechin can be used in studies related to bone remodeling, postmenopausal osteoporosis, inflammatory responses and oxidative stress. | ||||||||||||||||||||
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- [1]. Wong KC, et al. (-)-Epiafzelechin Protects against Ovariectomy-induced Bone Loss in Adult Mice and Modulate Osteoblastic and Osteoclastic Functions In Vitro. Nutrients. 2017 May 22;9(5):530. [Content Brief]
- [2]. Min KR, et al. (-)-Epiafzelechin: cyclooxygenase-1 inhibitor and anti-inflammatory agent from aerial parts of Celastrus orbiculatus. Planta medica. 1999 Jun;65(5):460-2. [Content Brief]
- [3]. Wong KC, et al. Development of a UPLC–MS/MS bioanalytical method for the pharmacokinetic study of (−)-epiafzelechin, a flavan-3-ol with osteoprotective activity, in C57BL/6J mice. Journal of Chromatography B. 2014;967:162-167.
- [4]. Hori K, et al. Antioxidant phenolic compounds from the rhizomes of Astilbe rivularis. Natural product research. 2018 Feb;32(4):453-456. [Content Brief]
- [5]. Wong KC. Characterization of the Osteoprotective Flavan-3-ols from Rhizoma Drynariae. The Hong Kong Polytechnic University. 2013
Keywords
