2715287-67-3
Chemical Structure
PI3Kα-IN-9
- CAS No.: 2715287-67-3
- Formula:C18H21N7O3
- Molecular Weight:383.40
IUPAC Name: (1'S,3S,3a'R,11a'S)-6-chloro-1'-(3-chloro-2-fluorophenyl)-3'-(cyclopropylmethyl)-2-oxo-1',3a',4',11a'-tetrahydro-3'H-spiro[indoline-3,2'-pyrrolo[3',2':4,5][1,3]oxazino[3,2-b]indazole]-8'-carboxylic acid
InChIKey: LOQNSAZUXOBMAX-UHFFFAOYSA-N
SMILES: NC1=NC2=CC(C3=NC(N4CCOCC4)=NC(N5CCOCC5)=N3)=CC=C2O1
Biological Activity: PI3Kα-IN-9 (compound 27) is a selective, long-acting and oral active PI3Kα inhibitor with IC50 values of 4.4, 128, 146 and 153 nM for PI3Kα, PI3Kγ, PI3Kδ and PI3Kβ, respectively. PI3Kα-IN-9 has antiproliferative activity and induces apoptosis. PI3Kα-IN-9 can be used for cancer research[1].
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PI3Kα-IN-9 | PI3Kα-IN-9 (compound 27) is a selective, long-acting and oral active PI3Kα inhibitor with IC50 values of 4.4, 128, 146 and 153 nM for PI3Kα, PI3Kγ, PI3Kδ and PI3Kβ, respectively. PI3Kα-IN-9 has antiproliferative activity and induces apoptosis. PI3Kα-IN-9 can be used for cancer research. | |||||||||||||||||||||
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Keywords
