3002399-75-6
3002399-75-6
Chemical Structure
CDK4-IN-3
- CAS No.: 3002399-75-6
- Formula:C26H32FN5O3
- Molecular Weight:481.56
InChIKey: TVXXLAJWEQEGRC-ZAWSQKNBSA-N
SMILES: CC(N1C2=CC(C3=NC(N[C@H]4[C@@H](COCC4)O)=NC=C3F)=CC=C2C(C(C)=C1C5CCCN5)=O)C
Biological Activity: CDK4-IN-3 (Compound 389) is a potent irreversible cyclin-dependent kinase 4 (CDK4) inhibitor (IC50=25 nM, >10-fold selective over CDK6). CDK4-IN-3 arrests the cell cycle at G₁ phase, and induces tumor cell apoptosis. CDK4-IN-3 is promising for research of solid tumors such as breast and lung cancers[1].
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CDK4-IN-3 | 98.07% | CDK4-IN-3 (Compound 389) is a potent irreversible cyclin-dependent kinase 4 (CDK4) inhibitor (IC50=25 nM, >10-fold selective over CDK6). CDK4-IN-3 arrests the cell cycle at G₁ phase, and induces tumor cell apoptosis. CDK4-IN-3 is promising for research of solid tumors such as breast and lung cancers. | ||||||||||||||||||||
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References
Keywords
