3052111-12-0
3052111-12-0
Chemical Structure
HDAC6-IN-48
- CAS No.: 3052111-12-0
- Formula:C24H21N3O4
- Molecular Weight:415.44
InChIKey: FCOHGKSSEJLMRS-UHFFFAOYSA-N
SMILES: COC1=CC=C(C=C1)C2=CC3=C(NC=C3CC(NC4=CC=C(C=C4)C(NO)=O)=O)C=C2
Biological Activity: HDAC6-IN-48 (compound 5i) is a potent and selective HDAC6 inhibitor with IC50 values of 5.16, 396.72, 638.08 nM for HDAC6, HDAC3, HDAC1, respectively. HDAC6-IN-48 induces apoptosis and cell cycle arrest at G0/G1 phase. HDAC6-IN-48 increases the protein expression of acetylated α-tubulin[1].
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HDAC6-IN-48 | HDAC6-IN-48 (compound 5i) is a potent and selective HDAC6 inhibitor with IC50 values of 5.16, 396.72, 638.08 nM for HDAC6, HDAC3, HDAC1, respectively. HDAC6-IN-48 induces apoptosis and cell cycle arrest at G0/G1 phase. HDAC6-IN-48 increases the protein expression of acetylated α-tubulin. | |||||||||||||||||||||
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References
Keywords
