3056515-10-4
Chemical Structure
AZD9750
- CAS No.: 3056515-10-4
- Formula:C43H48ClN9O2
- Molecular Weight:758.35
IUPAC Name: (S)-4-chloro-7-(3-(4-(4-((4-(6-(2,4-dioxotetrahydropyrimidin-1(2H)-yl)-1-methyl-1H-indol-2-yl)piperidin-1-yl)methyl)piperidin-1-yl)phenyl)piperidin-1-yl)-1H-indazole-3-carbonitrile
InChIKey: GOWJHJUMPVCHAN-JGCGQSQUSA-N
SMILES: N#CC1=NNC2=C(N3C[C@H](C4=CC=C(N5CCC(CC5)CN6CCC(C7=CC8=CC=C(N9C(NC(CC9)=O)=O)C=C8N7C)CC6)C=C4)CCC3)C=CC(Cl)=C12
Biological Activity: AZD9750 is an orally active, Cereblon (CRBN)-recruiting, androgen receptor (AR)-targeted PROTAC degrader. AZD9750 induces the proteasome-dependent degradation of both wild-type AR and the drug-resistant mutant ARL702H, thereby inhibiting the AR signaling pathway. AZD9750 suppresses tumor growth in mouse prostate cancer xenograft models and has been utilized in prostate cancer research[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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AZD9750 | 98.15% | AZD9750 is an orally active, Cereblon (CRBN)-recruiting, androgen receptor (AR)-targeted PROTAC degrader. AZD9750 induces the proteasome-dependent degradation of both wild-type AR and the drug-resistant mutant ARL702H, thereby inhibiting the AR signaling pathway. AZD9750 suppresses tumor growth in mouse prostate cancer xenograft models and has been utilized in prostate cancer research. | ||||||||||||||||||||
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Keywords
