614758-10-0
Chemical Structure
Ceftaroline chloride hydrochloride
Synonym(s): T-91825 chloride hydrochloride; PPI-0903M chloride hydrochloride
- CAS No.: 614758-10-0
- Formula:C22H22Cl2N8O5S4
- Molecular Weight:677.63
InChIKey: VIGGNRVCKFKUKC-KYZHTPFBSA-N
SMILES: OC(C1=C(SC2=NC(C3=CC=[N+](C)C=C3)=CS2)CS[C@@]([C@@H]4NC(/C(C5=NSC(N)=N5)=N\OCC)=O)([H])N1C4=O)=O.[Cl-].Cl
Biological Activity: Ceftaroline chloride hydrochloride (T-91825 chloride hydrochloride) is a cephalosporin compound and the active form of Ceftaroline fosamil (HY-14737). Ceftaroline chloride hydrochloride exhibits activity against Gram-positive bacteria, Gram-negative bacteria, and some anaerobic bacteria. Ceftaroline chloride hydrochloride binds to penicillin-binding proteins 2 and 2A, thereby inhibiting the synthesis of bacterial peptidoglycan and cell wall, and acts as a bactericide, synergist, and resistance inhibitor. Ceftaroline chloride hydrochloride can be used in research related to complicated skin and soft tissue infections, community-acquired pneumonia, Enterococcus faecalis infective endocarditis, and bacterial infections[1][2][3][4].
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Ceftaroline chloride hydrochloride | Ceftaroline chloride hydrochloride (T-91825 chloride hydrochloride) is a cephalosporin compound and the active form of Ceftaroline fosamil (HY-14737). Ceftaroline chloride hydrochloride exhibits activity against Gram-positive bacteria, Gram-negative bacteria, and some anaerobic bacteria. Ceftaroline chloride hydrochloride binds to penicillin-binding proteins 2 and 2A, thereby inhibiting the synthesis of bacterial peptidoglycan and cell wall, and acts as a bactericide, synergist, and resistance inhibitor. Ceftaroline chloride hydrochloride can be used in research related to complicated skin and soft tissue infections, community-acquired pneumonia, Enterococcus faecalis infective endocarditis, and bacterial infections. | |||||||||||||||||||||
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References
- [1]. Matzneller P, et al. Single- and Repeated-Dose Pharmacokinetics of Ceftaroline in Plasma and Soft Tissues of Healthy Volunteers for Two Different Dosing Regimens of Ceftaroline Fosamil. Antimicrobial agents and chemotherapy. 2016 Jun;60(6):3617-25.
- [2]. Cañas MA, et al. In vitro and in vivo activity of daptomycin plus ceftaroline for the treatment of experimental endocarditis due to Enterococcus faecalis with and without high-level aminoglycoside resistance. The Journal of antimicrobial chemotherapy. 2026 Apr 03;81(5):dkag136.
- [3]. Sader HS, et al. Antimicrobial activity and spectrum of PPI-0903M (T-91825), a novel cephalosporin, tested against a worldwide collection of clinical strains. Antimicrobial agents and chemotherapy. 2005 Aug;49(8):3501-12. [Content Brief]
- [4]. Iizawa Y, et al. In vitro antimicrobial activity of T-91825, a novel anti-MRSA cephalosporin, and in vivo anti-MRSA activity of its prodrug, TAK-599. Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy. 2004 Jun;10(3):146-56. [Content Brief]
