Antimicrobial activity and spectrum of PPI-0903M (T-91825), a novel cephalosporin, tested against a worldwide collection of clinical strains

  • Antimicrob Agents Chemother. 2005 Aug;49(8):3501-12. doi: 10.1128/AAC.49.8.3501-3512.2005.
Helio S Sader  1 ,  Thomas R Fritsche ,  Koné Kaniga ,  Yigong Ge ,  Ronald N Jones
Affiliations
  • 1. JMI Laboratories, Inc., 345 Beaver Kreek Centre, Suite A, North Liberty, IA 52317, USA. [email protected]
PMID: 16048970 DOI: 10.1128/AAC.49.8.3501-3512.2005
Abstract

PPI-0903M is a novel N-phosphono-type cephalosporin active against oxacillin-resistant staphylococci and many Other gram-positive organisms. This study evaluated the in vitro activity and spectrum of PPI-0903M against 1,478 recent clinical isolates collected from 80 medical centers (22 countries). PPI-0903M demonstrated broader in vitro activity against gram-positive bacteria, particularly against multidrug-resistant staphylococci and streptococci of current clinical concern, than currently available extended-spectrum cephalosporins while maintaining similar activity against gram-negative pathogens.

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