Ceftaroline hydrochloride
Based on 1 publication(s) in Google Scholar
Ceftaroline hydrochloride is a cephalosporin compound and the active form of Ceftaroline fosamil (HY-14737). Ceftaroline hydrochloride exhibits activity against Gram-positive bacteria, Gram-negative bacteria, and some anaerobic bacteria. Ceftaroline hydrochloride binds to penicillin-binding proteins 2 and 2A, thereby inhibiting the synthesis of bacterial peptidoglycan and cell wall, and acts as a bactericide, synergist, and resistance inhibitor. Ceftaroline hydrochloride can be used in research related to complicated skin and soft tissue infections, community-acquired pneumonia, Enterococcus faecalis infective endocarditis, and bacterial infections.
For research use only. We do not sell to patients.
- Purity: 98.0%
- Formula: C22H21ClN8O5S4
- Molecular Weight:641.17
-
Storage:
-80°C, stored under nitrogen
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- Purity & Documentation
- References
-
Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Ceftaroline hydrochloride
MoreAll Antibiotic Isoforms
More
Biological Activity
Description
In Vitro
Ceftaroline hydrochloride (T-91825 hydrochloride) in combination with Daptomycin (HY-B0108) exhibits synergistic in vitro activity against all tested endocarditis-associated HLAR and non-HLAR Enterococcus faecalis isolates at standard initial inoculum, prevents daptomycin resistance development, and shows bactericidal activity against two HLAR strains[2].
Ceftaroline (6-24 h) hydrochloride exhibits rapid, potent bactericidal activity against MRSA strains OFU4 and TY6242 at concentrations of 2 MIC and higher, reducing viable cell counts significantly over 24 h[4].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
Ceftaroline hydrochloride, delivered via its prodrug TAK-599 (20 mg/kg; s.c.; three times daily; starting 2 hours post infection or day 1 and day 2 post infection), significantly reduces MRSA bacterial counts in the lungs of neutropenic mice, even when treatment is initiated at a late stage of infection[4].
Ceftaroline hydrochloride, delivered via its prodrug TAK-599 (20 mg/kg; s.c.; three doses; at 2, 20, and 26 hours post infection), reduces MRSA bacterial counts in mouse thigh muscle to 0.1% or less of control levels[4].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Animal Model:ICR mice (4-week-old male; systemic MRSA infection model via intraperitoneal MRSA injection in 5% mucin)[4]
-
Dosage:1.08 mg/kg (strain TY5826); 1.46 mg/kg (strain TY6007); 4.81 mg/kg (strain TY5993); 2.09 mg/kg (strain TY6242)
-
Administration:s.c.; single dose; 1 hour post bacterial challenge
-
Result:Achieved ED50 of 1.08 mg/kg for protection against systemic MRSA infection (strain TY5826).
Achieved ED50 of 1.46 mg/kg for protection against systemic MRSA infection (strain TY6007).
Achieved ED50 of 4.81 mg/kg for protection against systemic MRSA infection (strain TY5993).
Achieved ED50 of 2.09 mg/kg for protection against systemic MRSA infection (strain TY6242).
-
Animal Model:CBA/J mice (5-week-old female; neutropenic MRSA pneumonia model via intranasal MRSA inoculation, neutropenia induced by intraperitoneal cyclophosphamide 4 days and 1 day pre-infection)[4]
-
Dosage:20 mg/kg
-
Administration:s.c.; three times daily; starting 2 hours post infection or day 1 and day 2 post infection
-
Result:Reduced lung bacterial counts by more than 99.9% compared to untreated day 3 controls when treatment started on day 1 after infection.
Reduced lung bacterial counts to 1/100 the level of day 1 controls when treatment started on day 1 after infection.
-
Animal Model:ICR mice (4-week-old male; MRSA thigh muscle infection model via intramuscular MRSA injection in left thigh)[4]
-
Dosage:20 mg/kg
-
Administration:s.c.; three doses; at 2, 20, and 26 hours post infection
-
Result:Reduced thigh muscle bacterial counts to 0.1% or less of untreated control levels.
Chemical Information
-
Appearance Solid
-
Molecular Weight 641.17
-
Formula C22H21ClN8O5S4
-
Color Light yellow to yellow
-
SMILES
C[N+]1=CC=C(C2=CSC(SC(CS[C@]3([H])[C@@H]4NC(/C(C5=NSC(N)=N5)=N\OCC)=O)=C(C([O-])=O)N3C4=O)=N2)C=C1.Cl
-
Shipping
Shipping with dry ice.
-
Storage
-80°C, stored under nitrogen
Publications (1)
-
Journal Impact Factor
-
Most Recent
-
J Infect Dis
Enhanced Killing of Methicillin-Resistant Staphylococcus aureus With Ceftaroline or Vancomycin in Combination With Carbapenems. [Abstract]2025 Jul 30;232(1):181-190. PMID: 39777519
Purity & Documentation
-
Data Sheet (291 KB)
-
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
-
Handling Instructions (2659 KB)
References
[3]. Sader HS, et al. Antimicrobial activity and spectrum of PPI-0903M (T-91825), a novel cephalosporin, tested against a worldwide collection of clinical strains. Antimicrobial agents and chemotherapy. 2005 Aug;49(8):3501-12. [Content Brief]
[4]. Iizawa Y, et al. In vitro antimicrobial activity of T-91825, a novel anti-MRSA cephalosporin, and in vivo anti-MRSA activity of its prodrug, TAK-599. Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy. 2004 Jun;10(3):146-56. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Ceftaroline hydrochloride Related Classifications
HY-105049A Related Classifications
Powered by Bioz
Keywords