2. Cell Cycle/DNA Damage Stem Cell/Wnt
  3. Casein Kinase
  4. Casein kinase 1δ-IN-1

Casein kinase 1δ-IN-1 (compound 822) is an inhibitor of casein kinase 1 delta (CK1δ), exhibits inhibition of greater than 5%. Casein kinase 1δ-IN-1 can be used for neurodegenerative disorders such as Alzheimer's disease research.

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Casein kinase 1δ-IN-1 Chemical Structure

Casein kinase 1δ-IN-1 Chemical Structure

CAS No. : 851871-94-8

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Based on 1 publication(s) in Google Scholar

Casein kinase 1δ-IN-1 Related Antibodies

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Description

Casein kinase 1δ-IN-1 (compound 822) is an inhibitor of casein kinase 1 delta (CK1δ), exhibits inhibition of greater than 5%. Casein kinase 1δ-IN-1 can be used for neurodegenerative disorders such as Alzheimer's disease research[1].

IC50 & Target[1]

CKIδ

 

Molecular Weight

229.26

Formula

C11H7N3OS
CAS No.
Appearance

Solid

Color

Off-white to light brown

SMILES

O=C(C1=NC=CC=C1)NC2=C(C#N)C=CS2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 41.67 mg/mL (181.76 mM; ultrasonic and warming and heat to 80°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.3619 mL 21.8093 mL 43.6186 mL
5 mM 0.8724 mL 4.3619 mL 8.7237 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 4.3619 mL 21.8093 mL 43.6186 mL 109.0465 mL
5 mM 0.8724 mL 4.3619 mL 8.7237 mL 21.8093 mL
10 mM 0.4362 mL 2.1809 mL 4.3619 mL 10.9047 mL
15 mM 0.2908 mL 1.4540 mL 2.9079 mL 7.2698 mL
20 mM 0.2181 mL 1.0905 mL 2.1809 mL 5.4523 mL
25 mM 0.1745 mL 0.8724 mL 1.7447 mL 4.3619 mL
30 mM 0.1454 mL 0.7270 mL 1.4540 mL 3.6349 mL
40 mM 0.1090 mL 0.5452 mL 1.0905 mL 2.7262 mL
50 mM 0.0872 mL 0.4362 mL 0.8724 mL 2.1809 mL
60 mM 0.0727 mL 0.3635 mL 0.7270 mL 1.8174 mL
80 mM 0.0545 mL 0.2726 mL 0.5452 mL 1.3631 mL
100 mM 0.0436 mL 0.2181 mL 0.4362 mL 1.0905 mL
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Casein kinase 1δ-IN-1 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Casein kinase 1δ-IN-1851871-94-8Casein KinaseAlzheimer's diseasepharmaceuticalneurodegenerative disordersInhibitorinhibitorinhibit

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