Casein kinase 1δ-IN-3

Cat. No.: HY-148455 Purity: 99.93%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

Casein kinase 1δ-IN-3 (Compound 23a) is a casein kinase 1 delta (CK1d) inhibitor with a pIC₅₀ of 6.5376 M.

For research use only. We do not sell to patients.

Casein kinase 1δ-IN-3 Chemical Structure

CAS No. : 349438-77-3

Size	Price	Stock	Quantity
5 mg	USD 85	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 145	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 300	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 485	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 780	In-stock	Estimated Time of Arrival: December 31
200 mg		Get quote
500 mg		Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

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Biological Activity
Purity & Documentation
References
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Description

Casein kinase 1δ-IN-3 (Compound 23a) is a casein kinase 1 delta (CK1d) inhibitor with a pIC₅₀ of 6.5376 M^[1].

IC₅₀ & Target^[1]

CKIδ

6.5376 M (pIC₅₀)

Molecular Weight

312.39

Formula

C₁₇H₁₆N₂O₂S

CAS No.

349438-77-3

Appearance

Solid

Color

White to off-white

SMILES

O=C(NC1=NC2=CC=C(C)C=C2S1)CC3=CC=CC=C3OC

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 62.5 mg/mL (200.07 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.2011 mL	16.0056 mL	32.0113 mL
5 mM	0.6402 mL	3.2011 mL	6.4023 mL
10 mM	0.3201 mL	1.6006 mL	3.2011 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo Dissolution Calculator

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Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.93%

Select Batch:

Data Sheet (272 KB) SDS (252 KB)

COA (250 KB) HNMR (258 KB) LCMS (266 KB)

Handling Instructions (2659 KB)

References

[1]. Makhuri FR, et al. Computer-aided scaffold hopping to identify a novel series of casein kinase 1 delta (CK1d) inhibitors for amyotrophic lateral sclerosis. Eur J Pharm Sci. 2015 Oct 12;78:151-62. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	3.2011 mL	16.0056 mL	32.0113 mL	80.0282 mL
	5 mM	0.6402 mL	3.2011 mL	6.4023 mL	16.0056 mL
	10 mM	0.3201 mL	1.6006 mL	3.2011 mL	8.0028 mL
	15 mM	0.2134 mL	1.0670 mL	2.1341 mL	5.3352 mL
	20 mM	0.1601 mL	0.8003 mL	1.6006 mL	4.0014 mL
	25 mM	0.1280 mL	0.6402 mL	1.2805 mL	3.2011 mL
	30 mM	0.1067 mL	0.5335 mL	1.0670 mL	2.6676 mL
	40 mM	0.0800 mL	0.4001 mL	0.8003 mL	2.0007 mL
	50 mM	0.0640 mL	0.3201 mL	0.6402 mL	1.6006 mL
	60 mM	0.0534 mL	0.2668 mL	0.5335 mL	1.3338 mL
	80 mM	0.0400 mL	0.2001 mL	0.4001 mL	1.0004 mL
	100 mM	0.0320 mL	0.1601 mL	0.3201 mL	0.8003 mL