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Art. -Nr.: HY-145830

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AC1-IN-1

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AC1-IN-1 is a potent and selective Adenylyl cyclase type 1 (AC1) inhibitor with an IC₅₀ of 0.54 μM. AC1-IN-1 displays modest antiallodynic effects in a mouse model of inflammatory pain.

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Reinheit: 99.32%
CAS. Nr.: 2762422-55-7
Formel: C₁₈H₁₈FN₅O₂
Molecular Weight:355.37

Speicherung:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month

AC1-IN-1 Chemical Structure

CAS. Nr.: 2762422-55-7

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Lösungsmittel & Löslichkeit
- In Vitro
Reinheit & Dokumentation
Verweise
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

AC1-IN-1 is a potent and selective Adenylyl cyclase type 1 (AC1) inhibitor with an IC₅₀ of 0.54 μM. AC1-IN-1 displays modest antiallodynic effects in a mouse model of inflammatory pain^[1].

IC₅₀ & Target

IC₅₀: 0.54 µM (AC1)^[1]

In Vitro

AC1-IN-1 (compound 38) (30 μM, 1 h) shows nontoxic to this human cell line in HEK293 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cytotoxicity Assay^[1]

Cell Line:

HEK293 cells
Concentration:

30 µM
Incubation Time:

1 hours
Result:

Showed nontoxic to HEK293 cells.

In Vivo

AC1-IN-1 (compound 38) (5.6 mg/kg; i.v.) displays modest, yet statistically significant, antiallodynic effects at 1 h post-treatment compared to the 0 min (allodynic) time point^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Male and female C57BL/6N mice (complete Freund’s adjuvant inflammatory pain model)^[1]
Dosage:

5.6 mg/kg (dissolved in 10% DMSO/10% Cremaphor/80% saline)
Administration:

Intravenous injection; 2 hours
Result:

Displayed modest, yet statistically significant, antiallodynic effects.

Chemical Information

CAS. Nr. 2762422-55-7
Appearance Solid
Molecular Weight 355.37
Formel C₁₈H₁₈FN₅O₂
Color White to off-white
SMILES

CCC1=CC(NC(N2N=C(C=C2NC(C3=C(C=CC(C)=C3)F)=O)C)=N1)=O
Versand

Room temperature in continental US; may vary elsewhere.

Speicherung

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Lösungsmittel & Löslichkeit

In Vitro:

DMSO : 25 mg/mL (70.35 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

2.8140 mL

14.0698 mL

28.1397 mL

5 mM

0.5628 mL

2.8140 mL

5.6279 mL

10 mM

0.2814 mL

1.4070 mL

2.8140 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (275 KB)
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Scott JA, et al. Optimization of a Pyrimidinone Series for Selective Inhibition of Ca2+/Calmodulin-Stimulated Adenylyl Cyclase 1 Activity for the Treatment of Chronic Pain. J Med Chem. 2022; 65(6):4667-4686. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	2.8140 mL	14.0698 mL	28.1397 mL	70.3492 mL
	5 mM	0.5628 mL	2.8140 mL	5.6279 mL	14.0698 mL
	10 mM	0.2814 mL	1.4070 mL	2.8140 mL	7.0349 mL
	15 mM	0.1876 mL	0.9380 mL	1.8760 mL	4.6899 mL
	20 mM	0.1407 mL	0.7035 mL	1.4070 mL	3.5175 mL
	25 mM	0.1126 mL	0.5628 mL	1.1256 mL	2.8140 mL
	30 mM	0.0938 mL	0.4690 mL	0.9380 mL	2.3450 mL
	40 mM	0.0703 mL	0.3517 mL	0.7035 mL	1.7587 mL
	50 mM	0.0563 mL	0.2814 mL	0.5628 mL	1.4070 mL
	60 mM	0.0469 mL	0.2345 mL	0.4690 mL	1.1725 mL

Keywords

100 mg

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Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Lösungsmittel & Löslichkeit
- In Vitro
Reinheit & Dokumentation
Verweise

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AC1-IN-1

GPCR/G Protein Compound Library

Heterocyclic Compound Library

Membrane Protein-targeted Compound Library

Highly Selective Inhibitors Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Bioactive Compound Library

High-Throughput Bioactive Compound Library

Lactylation Compound Library

Biologische Aktivität

Chemical Information

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

AC1-IN-1

GPCR/G Protein Compound Library

Heterocyclic Compound Library

Membrane Protein-targeted Compound Library

Highly Selective Inhibitors Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Bioactive Compound Library

High-Throughput Bioactive Compound Library

Lactylation Compound Library

Biologische Aktivität

Chemical Information

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

AC1-IN-1 Related Classifications

HY-145830 Related Classifications