ACSL5-IN-2
Based on 1 Customer Validation
ACSL5-IN-2 is a ACSL5 inhibitor that reduces the average body weight of diet-induced obese mice. ACSL5-IN-2 can be used for research on obesity.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- Reinheit : 99.51%
- CAS. Nr.: 3098297-74-3
- Formel: C29H33F2N3O6S
- Molecular Weight:589.65
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Speicherung:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biologische Aktivität
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Chemical Information
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Lösungsmittel & Löslichkeit
- Protokoll
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
Biologische Aktivität
Beschreibung
IC50 & Target
[1]|
ACSL5 |
In Vitro
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS. Nr. 3098297-74-3
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Appearance Solid
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Molecular Weight 589.65
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Formel C29H33F2N3O6S
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Color White to off-white
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SMILES
CC[C@@H](OC1=C(F)C(F)=C(C(NS(C2=CC=C(OCCN(C)C)C=C2)(=O)=O)=O)C=C1)C3=CC=C(OCC4CC4)C=N3
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Lösungsmittel & Löslichkeit
In Vitro:
DMSO : 25 mg/mL (42.40 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Protokoll
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Research Protocol for Metabolic Diseases
AMP-activated protein kinase, AMPK, is a conserved cellular energy sensor that responds to reduced cellular energy status and coordinates metabolism by increasing ATP-generating catabolic pathways while suppressing ATP-consuming anabolic processes. In metabolic disease research, the AMPK pathway is experimentally relevant because it regulates hepatic lipid synthesis, fatty acid oxidation, glucose production, skeletal-muscle glucose disposal, mTORC1-linked biosynthesis, autophagy, mitochondrial homeostasis, and whole-body energy balance. The central pathway logic is that energy stress, metformin, exercise-like stimulation, or direct AMPK activators increase AMPKα Thr172 phosphorylation and downstream substrate phosphorylation, including ACC and RAPTOR. Phosphorylation of ACC suppresses lipogenesis and supports fatty acid oxidation, whereas phosphorylation of RAPTOR suppresses mTORC1 signaling and links cellular energy status to growth and protein synthesis control. The pathway is linked
Reinheit & Dokumentation
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Data Sheet (273 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
Verweise
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| DMSO | 1 mM | 1.6959 mL | 8.4796 mL | 16.9592 mL | 42.3980 mL |
| 5 mM | 0.3392 mL | 1.6959 mL | 3.3918 mL | 8.4796 mL | |
| 10 mM | 0.1696 mL | 0.8480 mL | 1.6959 mL | 4.2398 mL | |
| 15 mM | 0.1131 mL | 0.5653 mL | 1.1306 mL | 2.8265 mL | |
| 20 mM | 0.0848 mL | 0.4240 mL | 0.8480 mL | 2.1199 mL | |
| 25 mM | 0.0678 mL | 0.3392 mL | 0.6784 mL | 1.6959 mL | |
| 30 mM | 0.0565 mL | 0.2827 mL | 0.5653 mL | 1.4133 mL | |
| 40 mM | 0.0424 mL | 0.2120 mL | 0.4240 mL | 1.0600 mL |
ACSL5-IN-2 Related Classifications
HY-177705 Related Classifications
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