(+)-Tuberine
(+)-Tuberine is an alkaloid found in Haplophyllum tuberculatum, with antibacterial and antifungal activities. (+)-Tuberine can be used in studies on antimicrobial natural products and microbial growth inhibition.
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- CAS. Nr.: 97400-75-4
- Formel: C27H35NO6
- Molecular Weight:469.58
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
Biologische Aktivität
Beschreibung
In Vitro
(+)-Tuberine (0.1, 1 μg/mL; 37°C; 24-48 h) inhibits the growth of S. aureus, B. subtilis, and E. coli in the disk diffusion assay; at 1 μg/mL, it produces inhibition zones of 10-15 mm against S. aureus and B. subtilis, while generating inhibition zones of 2-5 mm against E. coli[1].
(+)-Tuberine (1 μg/mL; 37°C; 24 h) significantly inhibits the growth of B. subtilis and S. aureus in the liquid culture plate count assay, with both dropping to below 106 CFU/mL at 24 h, while it only exerts weak inhibitory effects on E. coli[1].
(+)-Tuberine (0.1, 1 μg/mL; 37°C; 12 h) inhibits B. subtilis, E. coli, and S. aureus in turbidity assays, with inhibition rates of 84%, 48%, and 85% at 0.1 μg/mL, and 86%, 50%, and 94% at 1 μg/mL[1].
(+)-Tuberine (0.1, 1 μg/mL; 37°C; 24-48 h) inhibits the growth of S. cerevisiae in the disc diffusion assay, producing an inhibition zone of 6-10 mm at 1 μg/mL[1].
(+)-Tuberine (1 μg/mL; 37°C; 24 h) inhibits the growth of S. cerevisiae in liquid culture plate counting assays[1].
(+)-Tuberine (0.1, 1 μg/mL; 37°C; 12 h) exhibits inhibition rates of 84% and 91% against S. cerevisiae in turbidity assays[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
Chemical Information
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CAS. Nr. 97400-75-4
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Molecular Weight 469.58
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Formel C27H35NO6
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SMILES
[C@](OC(C)=O)(C)(C)[C@H]1O[C@@]([C@@H](COC2=CC=C(CCNC(=O)C3=CC=CC=C3)C=C2)O)(C)CC1
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Protokoll
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Research Protocol for Infectious Diseases
Infectious-disease experiments test how pathogens interact with host barriers, innate immune receptors, inflammatory signaling, pathogen replication, and tissue injury; pattern-recognition receptors such as TLRs, RIG-I-like receptors, NOD-like receptors, and inflammasomes detect microbial molecules and activate NF-κB, interferon, and cytokine responses. The central hypothesis is that infection severity reflects the balance between pathogen burden and host response: protective inflammation restricts pathogen growth, whereas excessive or mislocalized inflammation contributes to tissue damage and disease phenotype. Unresolved questions include which host pathways are protective versus pathogenic, why some infection models fail to translate to human disease, and which combined readouts best predict clinically relevant infection outcomes.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)