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Art. -Nr.: HY-163444

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Apoptosis inducer 15

Apoptosis inducer 15 (Compound 3) induces cell apoptosis and cell cycle arrest at G2/M phase. Apoptosis inducer 15 is cytotoxicitic without causing DNA fragmentation.

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Formel: C₁₁H₁₂O₅S
Molecular Weight:256.27

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (270 KB)

Apoptosis inducer 15 Chemical Structure

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Biologische Aktivität
- Beschreibung
- Cellular Effect
- In Vitro
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

Apoptosis inducer 15 (Compound 3) induces cell apoptosis and cell cycle arrest at G2/M phase. Apoptosis inducer 15 is cytotoxicitic without causing DNA fragmentation^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	1.2 μM Compound: 3	Antiproliferative activity against human A549 cells by MTT colorimetric assay Antiproliferative activity against human A549 cells by MTT colorimetric assay	[PMID: 38527380]
HeLa	IC₅₀	0.11 μM Compound: 3	Antiproliferative activity against human HeLa cells by MTT colorimetric assay Antiproliferative activity against human HeLa cells by MTT colorimetric assay	[PMID: 38527380]
HL-60	IC₅₀	2.07 μM Compound: 3	Antiproliferative activity against human HL-60 cells by MTT colorimetric assay Antiproliferative activity against human HL-60 cells by MTT colorimetric assay	[PMID: 38527380]
Jurkat	IC₅₀	1.01 μM Compound: 3	Antiproliferative activity against human Jurkat cells by MTT colorimetric assay Antiproliferative activity against human Jurkat cells by MTT colorimetric assay	[PMID: 38527380]
K562	IC₅₀	0.03 μM Compound: 3	Antiproliferative activity against human K562 cells by MTT colorimetric assay Antiproliferative activity against human K562 cells by MTT colorimetric assay	[PMID: 38527380]
MCF7	IC₅₀	3.38 μM Compound: 3	Antiproliferative activity against human MCF7 cells by MTT colorimetric assay Antiproliferative activity against human MCF7 cells by MTT colorimetric assay	[PMID: 38527380]
MDA-MB-231	IC₅₀	2.88 μM Compound: 3	Antiproliferative activity against human MDA-MB-231 cells by MTT colorimetric assay Antiproliferative activity against human MDA-MB-231 cells by MTT colorimetric assay	[PMID: 38527380]
MRC5	IC₅₀	>100 μM Compound: 3	Antiproliferative activity against human MRC5 cells by MTT colorimetric assay Antiproliferative activity against human MRC5 cells by MTT colorimetric assay	[PMID: 38527380]
Raji	IC₅₀	5.97 μM Compound: 3	Antiproliferative activity against human Raji cells by MTT colorimetric assay Antiproliferative activity against human Raji cells by MTT colorimetric assay	[PMID: 38527380]

In Vitro

Apoptosis inducer 15 inhibits proliferations of cancer cells K562, HL-60, Jurkat, Raji, MCF-7, MDA-MB-231 and HeLa, with IC₅₀s from 0.03-5.97 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

Molecular Weight 256.27
Formel C₁₁H₁₂O₅S
SMILES

O=C1C[C@H]2O[C@@H]([C@@H]([C@H]2O1)O)[C@@H](C3=CC=CS3)O
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (270 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Popsavin M, et al., Synthesis and biological activity of thiophene bioisosteres of natural styryl lactone goniofufurone and related compounds. Eur J Med Chem. 2024 Apr 5;269:116340. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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