CLX-0921
CLX-0921 is an orally active PPARγ agonist with an IC50 of 1.54 μM. CLX-0921 has a potent antihyperglycemic activity, and can be used for the study of type 2 diabetes.
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- CAS. Nr.: 249886-47-3
- Formel: C28H25NO7S
- Molecular Weight:519.57
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
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Biologische Aktivität
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PPARγ 1.54 μM (IC50) |
CLX-0921 (0.01 M, 0.1 M, 1.0 M, and 10 M) increases glucose uptake in 3T3-L1 adipocytes. CLX-0921 has potent antihyperglycemic activity with low adipogenic potential[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Male C57BL/KsJ-db/db and C57BL/6J-ob/ob mice (7-week-old)[1]
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Dosage:3.1 mg/kg, 6.3 mg/kg, and 12.5 mg/kg
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Administration:Oral gavage; once daily; for 19 days
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Result:Showed dose-dependent antihyperglycemic activity.
Chemical Information
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CAS. Nr. 249886-47-3
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Molecular Weight 519.57
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Formel C28H25NO7S
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SMILES
O=C(OC)/C(C1=CC=C(OC2=CC=C(CC(SC(N3)=O)C3=O)C=C2)C=C1)=C/C4=CC(OC)=CC(OC)=C4
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
CLX-0921 Related Classifications
HY-19394 Related Classifications
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