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Art. -Nr.: HY-186282

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DiPODS

DiPODS is a thiolate-targeted bioconjugation reagent with irreversible covalent binding activity. DiPODS can rebridge the broken disulfide bonds in antibodies/Fab fragments. DiPODS enables site-specific bioconjugation to generate homogeneous immunoconjugates. DiPODS can conjugate with various payloads via the primary amine at the end of its side chain. DiPODS is applicable to breast cancer-related research.

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CAS. Nr.: 2756320-37-1
Formel: C₂₃H₃₂N₆O₁₁S₂
Molecular Weight:632.66

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

DiPODS Chemical Structure

CAS. Nr.: 2756320-37-1

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- In Vitro
Chemical Information
Protokoll (1)
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

In Vitro

FabHER2-DiPODS-FITC (0.8 mg/mL; 30 min) retains specific binding to HER2-positive BT474 human breast cancer cells and exhibits higher immunoreactivity than a non-site-specific lysine-conjugated analogue^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.

Chemical Information

CAS. Nr. 2756320-37-1
Molecular Weight 632.66
Formel C₂₃H₃₂N₆O₁₁S₂
SMILES

O=C(CCOCCOCCOCCOCCN)NC1=CC(C2=NN=C(S(=O)(C)=O)O2)=CC(C3=NN=C(S(=O)(C)=O)O3)=C1
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Protokoll

All Animals and Diseases

Breast Cancer Modeling
Breast cancer is a heterogeneous cancer, and it has been distinguished into four subtypes: luminal A, luminal B, HER2-positive and basal-like. Molecular mutations, epigenetic alterations, hormone exposure and immune microenvironment are related to the progression of breast cancer.

Reinheit & Dokumentation

Handling Instructions (2659 KB)

Verweise

[1]. Khozeimeh Sarbisheh E, et al. DiPODS: A Reagent for Site-Specific Bioconjugation via the Irreversible Rebridging of Disulfide Linkages. Bioconjugate chemistry. 2020 Dec 16;31(12):2789-2806. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

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MOQ

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100 mg

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