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Art. -Nr.: HY-187236

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DOPE-PEG1000-CTP

Name: DOPE-PEG1000-CTP
Brand: MedChemExpress
SKU: HY-187236
Availability: PreOrder

(Synonyms: DOPE-PEG1000-APWHLSSQYSRT)

DOPE-PEG1000-CTP is a functionalized PEGylated lipid conjugate composed of three modular components: dioleoylphosphatidylethanolamine (DOPE) as the lipid anchoring group, a polyethylene glycol (PEG) spacer arm with a molecular weight of 1000 Da, and CTP (cardiotropic targeting peptide) (HY-P4094) as the terminal targeting/functional ligand. DOPE-PEG1000-CTP can be incorporated into liposomes, lipid nanoparticles (LNPs), or other nanocarriers, conferring cardiac targeting capability.

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Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

DOPE-PEG1000-CTP Chemical Structure

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Beschreibung

In Vitro

DOPE-PEG1000-CTP is specifically designed for active targeting nanomedicine applications. It can be incorporated into liposomes, lipid nanoparticles (LNPs), or other nanocarriers to confer ligand-directed targeting capability against brain endothelial cell receptors/CNS-specific transport mechanisms.
Composition and role of each component:
1. PEG1000 (polyethylene glycol, MW 1000): Hydrophilic polymer spacer arm that forms a steric corona around nanoparticles, reducing opsonization and reticuloendothelial system (RES) clearance, prolonging circulation half-life, and providing spatial separation between the lipid surface and targeting ligand.
2. CTP: Targeting ligand-can be reversibly linked (e.g., via enolase, thiol groups) to a carrier (e.g., miRNA), thereby enabling specific delivery to cardiomyocytes rather than all other organs.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .

Chemical Information

SMILES

[DOPE-PEG1000-CTP]
Synonyms

DOPE-PEG1000-APWHLSSQYSRT
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.