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Art. -Nr.: HY-158336

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E/Z-FETPY

E/Z-FETPY is an organo-diiron(I) complex with strong cytotoxicity in cancer cell lines. E/Z-FETPY induces ferroptosis in low-differentiated cell lines, such as A2780 cells.

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CAS. Nr.: 3056250-97-3
Formel: C₂₂H₂₄F₃Fe₂N₂O₅S₂
Molecular Weight:629.25

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (271 KB)

E/Z-FETPY Chemical Structure

CAS. Nr.: 3056250-97-3

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- In Vitro
- In Vivo
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

E/Z-FETPY is an organo-diiron(I) complex with strong cytotoxicity in cancer cell lines. E/Z-FETPY induces ferroptosis in low-differentiated cell lines, such as A2780 cells^[1].

In Vitro

E/Z-FETPY (72 h) shows cytotoxic potential that inhibits the growth of HCT 116, MCF7, and A2780 cells with IC₅₀ values 4 μM, 2.1 μM, and 2.5 μM, respectively^[1].
E/Z-FETPY (2.5 μM; 24-48 h) shows a time-dependent increase in iron uptake was detected upon incubation of A2780 cells. E/Z-FETPY suppresses hydrogen peroxide (H₂O₂) and peroxynitrite (O═NOO^-) along with amplified production of superoxide anion (O₂^-) and nitric oxide (NO)^[1].
FETPY (5 μM) induces significant morphological changes in murine B16-F1 and B16-F10 melanoma cells, leading to senescence and/or trans-differentiation into Schwann-like cells, thus significantly reducing their tumorigenic potential^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

FETPY (4 mg/kg; i.p.; once a day; for 3 weeks) significantly reduces the growth rate and tumor volume in both models^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

8-12 weeks old C57BL/6 male or female mice injected with B16-F1 or B16-F10 cells^[1]
Dosage:

4 mg/kg
Administration:

i.p.; once a day; for 3 weeks
Result:

Suppressed tumor growth in low- and high-grade syngeneic melanoma models.

Chemical Information

CAS. Nr. 3056250-97-3
Molecular Weight 629.25
Formel C₂₂H₂₄F₃Fe₂N₂O₅S₂
SMILES

FC(F)(S(=O)([O-])=O)F.C[s]c1[Fe]2([N]3=CC=C(N(C)C)C=C3)([])[Fe-]1([])([CH+]#O)C2=O.[+].C4CCCC4.C5CCCC5
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (271 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Ekatarina Mihajlović, et al. FETPY: a Diiron(I) Thio-Carbyne Complex with Prominent Anticancer Activity In Vitro and In Vivo. J Med Chem. 2024 May 9;67(9):7553-7568. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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