NISCH - nischarin Gene

Also Known as I-1; IR1; IRAS; hIRAS

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 11188

About NISCH

Cytogenetic location: 3p21.1 Genomic coordinates (GRCh38): 3:52,455,604-52,493,068 (from NCBI)

This gene has 14 transcripts (splice variants), 210 orthologues and 1 paralogue. Ubiquitous expression in testis (RPKM 30.5), prostate (RPKM 22.8) and 25 other tissues.

Summary

This gene encodes a nonadrenergic imidazoline-1 receptor protein that localizes to the cytosol and anchors to the inner layer of the plasma membrane. The orthologous mouse protein has been shown to influence cytoskeletal organization and cell migration by binding to alpha-5-beta-1 Integrin. In humans, this protein has been shown to bind to the adapter Insulin Receptor substrate 4 (IRS4) to mediate translocation of alpha-5 Integrin from the cell membrane to endosomes. Expression of this protein was reduced in human breast cancers while its overexpression reduced tumor growth and metastasis; possibly by limiting the expression of alpha-5 Integrin. In human cardiac tissue, this gene was found to affect cell growth and death while in neural tissue it affected neuronal growth and differentiation. Alternative splicing results in multiple transcript variants encoding differerent isoforms. Some isoforms lack the expected C-terminal domains of a functional Imidazoline Receptor. [provided by RefSeq, Jan 2013]

NISCH Products (3)

mRNA Protein Name
NM_001276293.2 NP_001263222.2 nischarin isoform 2
NM_001276294.2 NP_001263223.2 nischarin isoform 3
NM_007184.4 NP_009115.3 nischarin isoform 1

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence Verweise Source
enables identical protein binding IPI
IPI: Inferred from physical interaction
23386062 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
23386062 GOA
Cellular Component GO Annotation Evidence Verweise Source
located in cytosol IDA
IDA: Inferred from direct assay
15028622 GOA
located in plasma membrane IDA
IDA: Inferred from direct assay
15028622 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NISCH Protein Structure

PX

PX: PX domain (20 - 117)

LRR_8

LRR_8: Leucine rich repeat (289 - 344)

  • 0
  • 300
  • 600
  • 900
  • 1200
  • 1504 a.a.
Protein Preferred Names Protein Names

nischarin

  • I-1 receptor candidate protein

NISCH Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Verweise
Intra
NISCH Q9Y2I1 RAB9A Homo sapiens P51151
Y2H
23386062
Intra
NISCH Q9Y2I1 RAB9A Homo sapiens P51151
FRAP
23386062
Intra
NISCH Q9Y2I1 RAB9A Homo sapiens P51151
Pull Down
23386062
Intra
NISCH Q9Y2I1 RAB9A Homo sapiens P51151
IF
23386062
Cross
NISCH Q9Y2I1 Rab14 Rattus norvegicus P61107
IF
23386062
Cross
NISCH Q9Y2I1 Rab14 Rattus norvegicus P61107
Y2H
23386062
Cross
NISCH Q9Y2I1 Rab14 Rattus norvegicus P61107
FRAP
23386062
Cross
NISCH Q9Y2I1 Rab4a Rattus norvegicus P05714
Y2H
23386062
Cross
NISCH Q9Y2I1 Rab4a Rattus norvegicus P05714
FRAP
23386062
Cross
NISCH Q9Y2I1 Rab14 Rattus norvegicus P61107
CoIP
23386062
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Aplasia Of Lacrimal And Salivary Glands

  • ALSG

  • Congenital Absence Of Lacrimal Puncta And Salivary Glands

  • Xerostomia

  • Absence Of Salivary Glands

  • Parotid Aplasia Or Hypoplasia

  • Congenital Absence Of Lacrimal Puncta Or Salivary Glands

  • Alsg - [Aplasia Of Lacrimal Or Salivary Glands]
Cholestasis, Benign Recurrent Intrahepatic, 1

  • Benign Recurrent Intrahepatic Cholestasis

  • BRIC1

  • Summerskill Syndrome

  • Bric

  • Summerskill-Walshe-Tygstrup Syndrome

  • Cholestasis, Benign Recurrent Intrahepatic

  • Benign Recurrent Intrahepatic Cholestasis 1

  • Benign Recurrent Intrahepatic Cholestasis Type 1

  • Bric Type 1

  • Low Gamma-Gt Familial Intrahepatic Cholestasis

  • Recurrent Familial Intrahepatic Cholestasis

  • Cholestasis, Benign Recurrent Intrahepatic 1

  • Mild Atp8b1 Deficiency

  • Recurrent Familial Intrahepatic Cholestasis 1

  • Abcb11-Related Intrahepatic Cholestasis

  • Atp8b1-Related Intrahepatic Cholestasis

  • Cholestasis, Intrahepatic, Recurrent, Benign, Type 1

  • Progressive Intrahepatic Cholestasis

  • Cholestasis, Progressive Familial Intrahepatic 3

  • Bric - [Benign Recurrent Intrahepatic Cholestasis]
Hypertension, Essential

  • Essential Hypertension

  • Hypertension

  • High Blood Pressure

  • Hypertension, Essential, Susceptibility To

  • Hypertensive Disease

  • Primary Hypertension

  • EHT

  • Hypertension, Salt-Sensitive Essential, Susceptibility To

  • Hyperpiesia

  • Idiopathic Hypertension

  • Hypertensive Disorder

  • Hypertension, Essential, Susceptibility To, 3

  • Hypertension, Essential 3

  • Hypertension, Essential, Salt-Sensitive

  • Hypertension, Essential, Susceptibility To, 6

  • Hypertension, Essential 6

  • Hypertension, Salt-Sensitive Essential

  • Hypertension, Susceptibility To

  • Hypertension, Essential, Susceptibility To, 4

  • Hypertension, Essential 4

  • Hypertension, Essential, Susceptibility To, 2

  • Hypertension, Essential 2

  • Hypertension, Essential, Susceptibility To, 1

  • Hypertension, Essential 1

  • Hypertension, Essential, Susceptibility To, 5

  • Hypertension, Essential 5

  • Htn

  • Vascular Hypertensive Disorder

  • Systemic Primary Arterial Hypertension

  • Hbp - [High Blood Pressure]

  • Systemic Arterial Hypertensive Disorder

  • Elevated Blood Pressure

  • Arterial Hypertension Nos

  • Hypertension Nos

  • Benign Hypertension

  • Systemic Arterial Hypertension

  • Systemic Hypertension

  • Artery Htn

  • Benign Htn

  • Vascular Htn

  • Vascular Hypertension

  • Cholesterol Hypertension

  • Cholesterol Htn

  • Idiopathic Htn

  • Malignant Hypertension

  • Malignant Htn

  • Raised Blood Pressure

  • Cardiovascular Hypertension

  • Primary Htn - [Hypertension]

  • High Arterial Tension

  • High Blood Pressure Disorder

  • Ht - [Hypertension]

  • Htn - [Hypertension]

  • Hypertensive Vascular Disease

  • Hypertensive Vascular Degeneration
Sclerosing Cholangitis

  • Fibrosing Cholangitis

  • Cholangitis, Sclerosing

  • Primary Sclerosing Cholangitis
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-RS09309 NISCH Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus NISCH VGNC VGNC:32088
Rattus norvegicus NISCH RGD RGD:1306950
Felis catus NISCH VGNC VGNC:80640
Mus musculus NISCH MGD MGI:1928323
Canis familiaris NISCH VGNC VGNC:43822
Macaca mulatta NISCH VGNC VGNC:84147
Others NISCH NCBI