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ALOX15B - arachidonate 15-lipoxygenase type B Gene

Also Known as 15-LOX-2

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 247

About ALOX15B

Cytogenetic location: 17p13.1 Genomic coordinates (GRCh38): 17:8,039,059-8,049,134 (from NCBI)

This gene has 5 transcripts (splice variants), 218 orthologues and 5 paralogues. Biased expression in prostate (RPKM 42.3), esophagus (RPKM 13.5) and 2 other tissues.

Summary

This gene encodes a member of the Lipoxygenase family of structurally related nonheme iron dioxygenases involved in the production of fatty acid hydroperoxides. The encoded protein converts arachidonic acid exclusively to 15S-hydroperoxyeicosatetraenoic acid, while metabolizing linoleic acid less effectively. This gene is located in a cluster of related genes and a pseudogene that spans approximately 100 kilobases on the short arm of chromosome 17. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]

ALOX15B Products (3)

mRNA	Protein	Name
NM_001039130.2	NP_001034219.1	polyunsaturated fatty acid lipoxygenase ALOX15B isoform a
NM_001039131.2	NP_001034220.1	polyunsaturated fatty acid lipoxygenase ALOX15B isoform b
NM_001141.3	NP_001132.2	polyunsaturated fatty acid lipoxygenase ALOX15B isoform d

ALOX15B Protein Structure

PLAT

Lipoxygenase

0
200
400
600
676 a.a.

Protein Preferred Names	Protein Names
polyunsaturated fatty acid lipoxygenase ALOX15B	15-LOX-B

ALOX15B Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Verweise
Intra	ALOX15B	O15296	CTAG1A	Homo sapiens	P78358	Y2H Prey Pooling	32296183
Intra	ALOX15B	O15296	CTAG1A	Homo sapiens	P78358	Validated Y2H	32296183
Intra	ALOX15B	O15296	CTAG1A	Homo sapiens	P78358	Y2H Array	32296183
Intra	ALOX15B	O15296	TRAIP	Homo sapiens	Q9BWF2	Y2H Array	32296183
Intra	ALOX15B	O15296	TRAIP	Homo sapiens	Q9BWF2	Y2H Prey Pooling	32296183
Intra	ALOX15B	O15296	TRAIP	Homo sapiens	Q9BWF2	Validated Y2H	32296183
Intra	ALOX15B	O15296	CCDC115	Homo sapiens	Q96NT0	Y2H Prey Pooling	32296183
Intra	ALOX15B	O15296	CCDC115	Homo sapiens	Q96NT0	Y2H Array	32296183
Intra	ALOX15B	O15296	CCDC115	Homo sapiens	Q96NT0	Validated Y2H	32296183
Intra	ALOX15B	O15296	RARA	Homo sapiens	P10276	Validated Y2H	32296183
Intra	ALOX15B	O15296	RARA	Homo sapiens	P10276	Y2H Prey Pooling	32296183
Intra	ALOX15B	O15296	RARA	Homo sapiens	P10276	Y2H Array	32296183
Intra	ALOX15B	O15296	KCNF1	Homo sapiens	Q9H3M0	Y2H Array	32296183
Intra	ALOX15B	O15296	KCNF1	Homo sapiens	Q9H3M0	Y2H Prey Pooling	32296183
Intra	ALOX15B	O15296	KCNF1	Homo sapiens	Q9H3M0	Validated Y2H	32296183
Intra	ALOX15B	O15296	TRIM21	Homo sapiens	P19474	Y2H Array	32296183
Intra	ALOX15B	O15296	TRIM21	Homo sapiens	P19474	Validated Y2H	32296183
Intra	ALOX15B	O15296	TRIM21	Homo sapiens	P19474	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant ALOX15B Proteins

Art. -Nr.	Produktname	Accession	Reinheit
HY-P74436	15 Lipoxygenase 2 Protein, Human (sf9, His-GST)	O15296 (M1-I676)	≥ 85%, as determined by reducing SDS-PAGE.
HY-P74437	15 Lipoxygenase 2 Protein, Human (sf9)	O15296 (N-G&P, M1-I676)	≥ 90%, as determined by reducing SDS-PAGE.

ALOX15B Antibodies

Art. -Nr.	Produktname	Anwendung	Reactivity
HY-P811237	15-LO2 Antibody	WB, ICC/IF	Human, Mouse, Rat
HY-P89640	15-LO2 Antibody (YA8984)	WB, ICC/IF, IF-Tissue, IP, ELISA	human

Related Diseases

Diseases	Alias
Ectopia Lentis Et Pupillae	Ectopia Lentis With Ectopia Of Pupil ECTOLP
Autosomal Recessive Congenital Ichthyosis	Lamellar Ichthyosis Congenital Ichthyosiform Erythroderma Li Congenital Nonbullous Ichthyosiform Erythroderma Arci Congenital Lamellar Ichthyosis Nonbullous Congenital Ichthyosiform Erythroderma Cie Congenital Non-Bullous Ichthyosiform Erythroderma Erythrodermic Ichthyosis Nbcie Ncie Non-Bullous Congenital Ichthyosiform Erythroderma Collodion Baby Ichthyosis, Lamellar Non Bullous Congenital Ichthyosiform Erythroderma Ichthyosiform Erythroderma, Brocq Congenital, Nonbullous Form Ichthyosiform Erythroderma, Congenital, Nonbullous, 1 Collodion Baby Syndrome Ichthyoses, Lamellar Nbie Nonbullous Ichthyosiform Erythroderma Classic Lamellar Ichthyosis Ichthyosiform Erythroderma Nonbullous Congenital Ichthyosiform Erythroderma Congenital Ichthyosis, Congenital, Autosomal Recessive Ichthyosiform Erythroderma, Congenital Collodion Fetus Non-Bullous Ichthyosiform Erythroderma
Prostate Cancer	Prostate Carcinoma Prostate Cancer, Familial Prostate Neoplasm Prostate Cancer, Somatic Prostate Cancer, Susceptibility To Prostatic Cancer Prostatic Neoplasms Hereditary Prostate Cancer Prostatic Neoplasm Cancer Of Prostate Carcinoma Of Prostate Familial Prostate Cancer Familial Prostate Carcinoma Malignant Tumor Of Prostate Malignant Neoplasm Of Prostate Prostate Cancer, Familial, Susceptibility To Malignant Tumor Of The Prostate Ngp - New Growth Of Prostate Tumor Of The Prostate Prostate Cancer, Hereditary Cancer Of The Prostate Malignant Neoplasm Of The Prostate Prostatic Carcinoma PC Prca Cancer, Prostate Malignant Prostatic Tumour Malignant Tumour Of Prostate Primary Prostate Cancer Primary Malignant Neoplasm Of Prostate Prostate Gland Cancer
Ichthyosis	Ichthyoses Non-Syndromic Ichthyosis Congenital Ichthyosis
Ichthyosis, Congenital, Autosomal Recessive 3	Autosomal Recessive Congenital Ichthyosis 3 ARCI3 Lamellar Ichthyosis 5 Collodion Baby, Self-Healing Ichthyosis, Lamellar, 5, Formerly Li5, Formerly Li5 Self-Healing Collodion Baby Ichthyosis, Congenital, Autosomal Recessive, Type 3
Primary Cutaneous Amyloidosis	Plca Primary Localized Cutaneous Amyloidosis Familial Primary Localized Cutaneous Amyloidosis Amyloidosis Ix Lichen Amyloidosis Familial Amyloidosis, Primary Cutaneous Pca Amyloidosis 9 Amyloidosis Familial Cutaneous Lichen Fplca Familial Lichen Amyloidosis
Squamous Cell Carcinoma, Head And Neck	Squamous Cell Carcinoma Of The Head And Neck HNSCC Head And Neck Squamous Cell Carcinoma Squamous Cell Carcinoma Of Lip Squamous Cell Carcinoma, Head And Neck, Somatic Carcinoma Of The Head And Neck Squamous Cell Carcinomas Of Head And Neck Scchn Squamous Cell Carcinoma Of The Hypopharynx Squamous Cell Carcinoma Of The Oropharynx Squamous Cell Carcinoma Of Salivary Glands Squamous Cell Carcinoma Of The Nasal Cavity And Paranasal Sinuses Squamous Cell Carcinoma Of The Nasal Cavity And Sinuses Squamous Cell Carcinoma Of The Oral Cavity Squamous Cell Carcinoma Of The Lip Carcinoma, Squamous Cell Of Head And Neck Lip Squamous Cell Carcinoma Carcinoma, Squamous Cell, Head And Neck Salivary Gland Squamous Cell Carcinoma Cancer Of Head And Neck Squamous Cell Carcinoma Of Oropharynx Nos

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)

Art. -Nr.	Produktname	Wirkung	Reinheit	Rare Diseases
HY-RS00619	ALOX15B Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS27130	Alox15b Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	ALOX15B	VGNC	VGNC:59756
Macaca mulatta	ALOX15B	VGNC	VGNC:69797
Canis familiaris	ALOX15B	VGNC	VGNC:37812
Rattus norvegicus	ALOX15B	RGD	RGD:628809
Mus musculus	ALOX15B	MGD	MGI:1098228
Bos taurus	ALOX15B	VGNC	VGNC:55769
Others	ALOX15B	NCBI