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Art. -Nr.: HY-151941

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MtInhA-IN-1

MtInhA-IN-1 is a selective and orally active Mycobacterium tuberculosis NADH-dependent enoyl-acyl carrier protein reductase (MtInhA) inhibitor with an IC₅₀ of 0.23 μM. MtInhA-IN-1 potently against M. tuberculosis H37Rv strain with a MIC value of 0.4 μM.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

CAS. Nr.: 3037822-97-9
Formel: C₂₁H₂₂BrN₃
Molecular Weight:396.32

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (283 KB)

MtInhA-IN-1 Chemical Structure

CAS. Nr.: 3037822-97-9

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- Cellular Effect
- In Vitro
- In Vivo
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target

IC50: 0.23 μM (Mycobacterium tuberculosis NADH-dependent enoyl-acyl carrier protein reductase (MtInhA))^[1]
MIC: 0.4 μM (M. tuberculosis H37Rv strain), 0.1 μM (M. tuberculosis strains PT2), 0.2 μM (M. tuberculosis strains PT12), and 0.1 μM (M. tuberculosis strains PT20)^[1]

Cellular Effect

Cell Line	Type	Value	Description	References
HepG2	CC₅₀	>20 μM Compound: 19k	Cytotoxicity against human HepG2 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay Cytotoxicity against human HepG2 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay	[PMID: 36435016]
HepG2	CC₅₀	18.3 μM Compound: 19k	Cytotoxicity against human HepG2 cells assessed as reduction in cell viability incubated for 72 hrs by neutral red uptake assay Cytotoxicity against human HepG2 cells assessed as reduction in cell viability incubated for 72 hrs by neutral red uptake assay	[PMID: 36435016]
Vero	CC₅₀	>20 μM Compound: 19k	Cytotoxicity against African green monkey Vero cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay Cytotoxicity against African green monkey Vero cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay	[PMID: 36435016]
Vero	CC₅₀	12.2 μM Compound: 19k	Cytotoxicity against African green monkey Vero cells assessed as reduction in cell viability incubated for 72 hrs by neutral red uptake assay Cytotoxicity against African green monkey Vero cells assessed as reduction in cell viability incubated for 72 hrs by neutral red uptake assay	[PMID: 36435016]

In Vitro

MtInhA-IN-1 (compound 19k) shows inhibitory activity against a panel of multidrug-resistant M. tuberculosis strains, M. tuberculosis strains PT2, PT12, and PT20. The MIC values of 0.1 μM, 0.2 μM, and 0.1 μM for PT2, PT12, and PT20, respectively. In addition, MtInhA-IN-1 has low cytotoxicity against HepG2 and Vero cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

MtInhA-IN-1 (compound 19k; 300-450 μM/kg; p.o; daily; for 14 days) shows bacteriostatic effect in a murine model of tuberculosis^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

M. tuberculosis-infected mice ^[1]
Dosage:

300 μM/kg and 450 μM/kg
Administration:

Oral administration; daily; for 14 days
Result:

Reduced the growth of bacilli in the lungs of mice.

Chemical Information

CAS. Nr. 3037822-97-9
Molecular Weight 396.32
Formel C₂₁H₂₂BrN₃
SMILES

CC1=NC2=C(C(NC3=CC=C(C=C3)N4CCCCC4)=C1)C=C(C=C2)Br
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (283 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Josiane Delgado Paz, et al. Novel 4-aminoquinolines: Synthesis, inhibition of the Mycobacterium tuberculosis enoyl-acyl carrier protein reductase, antitubercular activity, SAR, and preclinical evaluation. Eur J Med Chem. 2023 Jan 5;245(Pt 1):114908. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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