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Art. -Nr.: HY-178048

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Neuroprotective agent 13

Neuroprotective agent 13 is a brain-penetrant 1H-benzo[d]imidazoles compound with neuroprotective effect. Neuroprotective agent 13 can activate autophagy and clear SCMAS accumulation from iPSC-derived neural progenitor cells. Neuroprotective agent 13 can be used for the research of neurological disease, such as neuronal ceroid lipofuscinoses (NCLs).

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CAS. Nr.: 3086460-35-4
Formel: C₁₆H₁₄F₃N₃O
Molecular Weight:321.30

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (268 KB)

Neuroprotective agent 13 Chemical Structure

CAS. Nr.: 3086460-35-4

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Biologische Aktivität
- Beschreibung
- In Vitro
- Parmacokinetics
- In Vivo
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

In Vitro

Neuroprotective agent 13 (Compound 9b) (10 μM, 24 h) significantly protects the viability of neural progenitor cells (NPCs) with CLN3 induced pluripotent stem cells (iPSCs), with a cell viability of 132.18%^[1].
Neuroprotective agent 13 (Compound 9b) clears the abnormal accumulation of subunit c of mitochondrial ATP synthase (SCMAS) in iPSC-NPC cells with CLN3^[1].
Neuroprotective agent 13 (10 μM, 24 h) activates the autophagic pathway in iPSC-NPC cells with CLN3^[1].
Neuroprotective agent 13 (1-10 μM) does not activate Kv7.2/7.3 voltage-gated potassium channels^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Autophagy Assay^[1]

Cell Line:

IPSC-NPC cells with CLN3
Concentration:

10 μM
Incubation Time:

24 h
Result:

Increased the immunofluorescence of autophagic cells.

Parmacokinetics

Species	Dose	Route	T_max	C_max	AUC_0-∞	T_1/2	CL/F	MRT_0-∞	V_ss	F
Mice^[1]	1 mg/kg	i.v.	0.25 h	378 ng/mL	482.43 ng·h/mL	5.43 h	3.66 L/h/kg	1.09 h	3.96 L/kg	/
Mice^[1]	10 mg/kg	p.o.	0.49 h	1793.4 ng/mL	2728.03 ng·h/mL	3.6 h	3.67 L/h/kg	1.93 h	/	56.5 %

In Vivo

Neuroprotective agent 13 (Compound 9b) (1 mg/kg for i.v., 10 mg/kg for p.o.) shows high brain penetration, with the brain/plasma concentration ratio of 3.5 and 5.6 in Balb/c mice^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS. Nr. 3086460-35-4
Molecular Weight 321.30
Formel C₁₆H₁₄F₃N₃O
SMILES

OCC1=NC2=C(C=C(C=C2)NCC3=CC=C(C=C3)C(F)(F)F)N1
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (268 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Simeon P, et al. Discovery of Functionalized 1H-Benzo[d]imidazoles That Confer Protective Effects in a Phenotypic CLN3 Disease Patient-Derived iPSC Model. J Med Chem. 2025 Sep 11;68(17):18530-18552. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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