Art. -Nr.: HY-102010

Pancratistatin

Name: Pancratistatin
Brand: MedChemExpress
SKU: HY-102010
Price: 1000.00 USD
Availability: InStock
Rating: 5 (1 reviews)

(Synonyms: (+)-Pancratistatin)

Pancratistatin is an isoquinoline alkaloid that can be isolated from Hymenocallis littoralis. Pancratistatin induces apoptosis of human melanoma cells. Pancratistatin can be used for the research of neuroblastoma, leukemia and breast cancer.

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CAS. Nr.: 96203-70-2
Formel: C₁₄H₁₅NO₈
Molecular Weight:325.27

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (271 KB)

Pancratistatin Chemical Structure

CAS. Nr.: 96203-70-2

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- Cellular Effect
Chemical Information
Protokoll (5)
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

Cellular Effect

Cell Line	Type	Value	Description	References
BXPC-3	ED₅₀	0.02 μg/mL Compound: 1	Growth inhibition of human BXPC3 cells after 48 hrs Growth inhibition of human BXPC3 cells after 48 hrs	[PMID: 17346078]
BXPC-3	ED₅₀	0.043 μg/mL Compound: 1	Cytotoxicity against human BxPC3 cells after 48 hrs by SRB assay Cytotoxicity against human BxPC3 cells after 48 hrs by SRB assay	[PMID: 16124772]
BXPC-3	GI₅₀	0.02 μg/mL Compound: 1a	Cytotoxicity against human BxPC3 cells after 48 hrs by SRB assay Cytotoxicity against human BxPC3 cells after 48 hrs by SRB assay	[PMID: 22413911]
BXPC-3	GI₅₀	0.02 μg/mL Compound: 1a	Cytotoxicity against human BxPC3 cells Cytotoxicity against human BxPC3 cells	[PMID: 15043403]
DU-145	ED₅₀	0.037 μg/mL Compound: 1	Cytotoxicity against human DU145 cells after 48 hrs by SRB assay Cytotoxicity against human DU145 cells after 48 hrs by SRB assay	[PMID: 16124772]
DU-145	GI₅₀	0.015 μg/mL Compound: 1	Growth inhibition of human DU145 cells after 48 hrs Growth inhibition of human DU145 cells after 48 hrs	[PMID: 17346078]
DU-145	GI₅₀	0.015 μg/mL Compound: 1a	Cytotoxicity against human DU145 cells after 48 hrs by SRB assay Cytotoxicity against human DU145 cells after 48 hrs by SRB assay	[PMID: 22413911]
DU-145	GI₅₀	0.015 μg/mL Compound: 1a	Cytotoxicity against human DU145 cells Cytotoxicity against human DU145 cells	[PMID: 15043403]
DU-145	GI₅₀	0.016 μg/mL Compound: 1	Growth inhibition of human DU145 cells Growth inhibition of human DU145 cells	[PMID: 16441059]
KM-20L2	ED₅₀	0.048 μg/mL Compound: 1	Cytotoxicity against human KM20L2 cells after 48 hrs by SRB assay Cytotoxicity against human KM20L2 cells after 48 hrs by SRB assay	[PMID: 16124772]
KM-20L2	GI₅₀	0.025 μg/mL Compound: 1	Growth inhibition of human KM20L2 cells after 48 hrs Growth inhibition of human KM20L2 cells after 48 hrs	[PMID: 17346078]
KM-20L2	GI₅₀	0.025 μg/mL Compound: 1a	Cytotoxicity against human KM20L2 cells after 48 hrs by SRB assay Cytotoxicity against human KM20L2 cells after 48 hrs by SRB assay	[PMID: 22413911]
KM-20L2	GI₅₀	0.025 μg/mL Compound: 1a	Cytotoxicity against human KM20L2 cells Cytotoxicity against human KM20L2 cells	[PMID: 15043403]
KM-20L2	GI₅₀	0.026 μg/mL Compound: 1	Growth inhibition of human KM20L2 cells Growth inhibition of human KM20L2 cells	[PMID: 16441059]
MCF7	ED₅₀	0.023 μg/mL Compound: 1	Growth inhibition of human MCF7 cells after 48 hrs Growth inhibition of human MCF7 cells after 48 hrs	[PMID: 17346078]
MCF7	ED₅₀	0.035 μg/mL Compound: 1	Cytotoxicity against human MCF7 cells after 48 hrs by SRB assay Cytotoxicity against human MCF7 cells after 48 hrs by SRB assay	[PMID: 16124772]
MCF7	GI₅₀	0.023 μg/mL Compound: 1a	Cytotoxicity against human MCF7 cells after 48 hrs by SRB assay Cytotoxicity against human MCF7 cells after 48 hrs by SRB assay	[PMID: 22413911]
MCF7	GI₅₀	0.023 μg/mL Compound: 1a	Cytotoxicity against human MCF7 cells Cytotoxicity against human MCF7 cells	[PMID: 15043403]
MCF7	GI₅₀	0.032 μg/mL Compound: 1	Growth inhibition of human MCF7 cells Growth inhibition of human MCF7 cells	[PMID: 16441059]
MCF7	IC₅₀	0.071 μM Compound: 5	Cytotoxicity against human MCF7 cells Cytotoxicity against human MCF7 cells	[PMID: 22921081]
NCI-H460	ED₅₀	0.029 μg/mL Compound: 1	Cytotoxicity against human NCI-H460 cells after 48 hrs by SRB assay Cytotoxicity against human NCI-H460 cells after 48 hrs by SRB assay	[PMID: 16124772]
NCI-H460	GI₅₀	0.032 μg/mL Compound: 1	Growth inhibition of human NCI-H460 cells after 48 hrs Growth inhibition of human NCI-H460 cells after 48 hrs	[PMID: 17346078]
NCI-H460	GI₅₀	0.032 μg/mL Compound: 1a	Cytotoxicity against human NCI-H460 cells after 48 hrs by SRB assay Cytotoxicity against human NCI-H460 cells after 48 hrs by SRB assay	[PMID: 22413911]
NCI-H460	GI₅₀	0.032 μg/mL Compound: 1a	Cytotoxicity against human NCI-H460 cells Cytotoxicity against human NCI-H460 cells	[PMID: 15043403]
NCI-H460	GI₅₀	0.048 μg/mL Compound: 1	Growth inhibition of human NCI-H460 cells Growth inhibition of human NCI-H460 cells	[PMID: 16441059]
P388	ED₅₀	<0.01 μg/mL Compound: 1	Cytotoxicity against mouse P388 cells Cytotoxicity against mouse P388 cells	[PMID: 6549467]
P388	ED₅₀	0.01 μg/mL Compound: 1	Growth inhibition of mouse P388 cells Growth inhibition of mouse P388 cells	[PMID: 8277308]
P388	ED₅₀	0.017 μg/mL Compound: 1	Growth inhibition of murine P388 cells after 48 hrs Growth inhibition of murine P388 cells after 48 hrs	[PMID: 17346078]
P388	ED₅₀	0.017 μg/mL Compound: 1a	Cytotoxicity against mouse P388 cells after 48 hrs by cell counting Cytotoxicity against mouse P388 cells after 48 hrs by cell counting	[PMID: 22413911]
P388	ED₅₀	0.017 μg/mL Compound: 1a	Cytotoxicity against mouse P388 cells Cytotoxicity against mouse P388 cells	[PMID: 15043403]
P388	ED₅₀	0.039 μg/mL Compound: 1	Growth inhibition of mouse P388 cells Growth inhibition of mouse P388 cells	[PMID: 16441059]
P388	ED₅₀	0.039 μg/mL Compound: 1, PST	Cytotoxicity against mouse P388 cells Cytotoxicity against mouse P388 cells	[PMID: 18225861]
P388	ED₅₀	0.048 μg/mL Compound: 1	Cytotoxicity against mouse P388 cells Cytotoxicity against mouse P388 cells	[PMID: 16124772]
SF-268	ED₅₀	0.032 μg/mL Compound: 1	Cytotoxicity against human SF268 cells after 48 hrs by SRB assay Cytotoxicity against human SF268 cells after 48 hrs by SRB assay	[PMID: 16124772]
SF-268	GI₅₀	0.014 μg/mL Compound: 1	Growth inhibition of human SF268 cells after 48 hrs Growth inhibition of human SF268 cells after 48 hrs	[PMID: 17346078]
SF-268	GI₅₀	0.014 μg/mL Compound: 1a	Cytotoxicity against human SF268 cells after 48 hrs by SRB assay Cytotoxicity against human SF268 cells after 48 hrs by SRB assay	[PMID: 22413911]
SF-268	GI₅₀	0.014 μg/mL Compound: 1a	Cytotoxicity against human SF268 cells Cytotoxicity against human SF268 cells	[PMID: 15043403]
Vero	IC₅₀	0.016 μg/mL Compound: 4	Antiviral activity against Yellow fever virus Ashibi infected in african green monkey Vero cells assessed as inhibition of virus-induced cytopathic effect by MTT assay Antiviral activity against Yellow fever virus Ashibi infected in african green monkey Vero cells assessed as inhibition of virus-induced cytopathic effect by MTT assay	[PMID: 1336040]
Vero	IC₅₀	0.022 μg/mL Compound: 4	Antiviral activity against Japanese encephalitis virus Nakayama infected in african green monkey Vero cells assessed as inhibition of virus-induced cytopathic effect by MTT assay Antiviral activity against Japanese encephalitis virus Nakayama infected in african green monkey Vero cells assessed as inhibition of virus-induced cytopathic effect by MTT assay	[PMID: 1336040]
Vero	IC₅₀	0.063 μg/mL Compound: 4	Antiviral activity against Dengue virus type 4 infected in african green monkey Vero cells after 6 days by plaque reduction assay Antiviral activity against Dengue virus type 4 infected in african green monkey Vero cells after 6 days by plaque reduction assay	[PMID: 1336040]
Vero	IC₅₀	0.16 μg/mL Compound: 4	Antiviral activity against Rift Valley fever virus infected in african green monkey Vero cells after 6 days by plaque reduction assay Antiviral activity against Rift Valley fever virus infected in african green monkey Vero cells after 6 days by plaque reduction assay	[PMID: 1336040]

Chemical Information

CAS. Nr. 96203-70-2
Molecular Weight 325.27
Formel C₁₄H₁₅NO₈
SMILES

O=C1N[C@@]2([H])[C@H](O)[C@H](O)[C@@H](O)[C@H](O)[C@]2([H])C3=C1C(O)=C4C(OCO4)=C3
Synonyms

(+)-Pancratistatin
Structure Classification
- Alkaloids
- Isoquinoline Alkaloids
Initial Source
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Protokoll

All Cell Biology Signal Pathway Related Animals and Diseases

Apoptosis
Apoptosis, also called programmed cell death, is generally characterized by distinct morphological characteristics.
TUNEL staining for apoptotic DNA fragmentation
TUNEL staining detects DNA strand breaks by using terminal deoxynucleotidyl transferase to add labeled nucleotides to exposed 3′-OH DNA termini, generating either microscopic staining in fixed cells or tissue sections, or fluorescence/cytometric signal in cell suspensions. TUNEL positivity reflects DNA fragmentation but should not be interpreted alone as definitive apoptosis, because TUNEL can also label necrotic, autolytic, mechanically damaged, or DNA-repair-associated DNA breaks.
Annexin V plus membrane-impermeant dye apoptosis staining
Annexin V-based apoptosis assays rely on the detection of phosphatidylserine (PS) externalization from the inner leaflet of the plasma membrane to the outer leaflet, an early biochemical hallmark of apoptosis. Fluorescently labeled Annexin V binds PS in a calcium-dependent manner, enabling identification of early apoptotic cells by flow cytometry or fluorescence microscopy. When combined with a membrane-impermeant DNA-binding dye (e. g. , propidium iodide), this approach allows discrimination between viable (Annexin V−/dye−), early apoptotic (Annexin V+/dye−), and late apoptotic or necrotic (Annexin V+/dye+) cell populations by assessing membrane integrity and PS exposure.
Apoptosis Solutions
Apoptosis is a regulated, generally non-lytic cell-death pathway that removes unwanted, damaged, infected, or abnormal cells through coordinated morphological changes, caspase activation, DNA fragmentation, and membrane remodeling. The intrinsic apoptosis pathway is controlled mainly by mitochondrial outer membrane permeabilization, BCL-2 family proteins, cytochrome c release, apoptosome formation, caspase-9 activation, and downstream executioner caspase-3/7 activation. The extrinsic apoptosis pathway is initiated by death receptors such as Fas, TNFR, and TRAIL receptors, which recruit adaptor proteins and activate caspase-8 before engaging executioner caspases or mitochondrial amplification through BID cleavage. Apoptosis is linked to many phenotypes, including cancer cell killing, tissue homeostasis, immune regulation, neurodegeneration, infection response, and treatment-induced cytotoxicity; unresolved questions include how apoptosis interacts with necroptosis, pyroptosis, ferroptos
Breast Cancer Modeling
Breast cancer is a heterogeneous cancer, and it has been distinguished into four subtypes: luminal A, luminal B, HER2-positive and basal-like. Molecular mutations, epigenetic alterations, hormone exposure and immune microenvironment are related to the progression of breast cancer.

Reinheit & Dokumentation

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Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (271 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Chatterjee SJ, et al. Sensitization of human melanoma cells by tamoxifen to apoptosis induction by pancratistatin, a nongenotoxic natural compound. Melanoma Res. 2011 Feb;21(1):1-11. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Pancratistatin

Biologische Aktivität

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Cellular Effect

Chemical Information

Protokoll

Reinheit & Dokumentation

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Bioz

Keywords

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Pancratistatin

Biologische Aktivität

Beschreibung

Cellular Effect

Chemical Information

Protokoll

Reinheit & Dokumentation

Verweise

Calculators

Help & FAQs

Pancratistatin Related Classifications

HY-102010 Related Classifications

Bioz

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