80 Results for "

IgG1 mAb

" in MedChemExpress (MCE) Product Catalog:
Products (80)

80 Results for "IgG1 mAb" in MCE Product Catalog:

11
11 Publications Verification
Art. -Nr.: HY-108730
CAS. Nr.: 1537032-82-8
Synonyms: Anti-Human PD-L1, Human Antibody; MSB 0010718C; MSB0010718C

Target:  

PD-1/PD-L1

Forschungsgebiete:  

Inflammation/Immunology Cancer

Avelumab (Anti-Human PD-L1) a fully human IgG1 anti-PD-L1 monoclonal antibody (mAb) with potential antibody-dependent cell-mediated cytotoxicity (ADCC). Avelumab enhances ADCC on several cancer cell lines expressing PD-L1. Avelumab can be used for the study of chordoma .
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11
11 Publications Verification
Art. -Nr.: HY-108730A
CAS. Nr.: 1537032-82-8
Reinheit:  96.02%

Target:  

PD-1/PD-L1

Forschungsgebiete:  

Inflammation/Immunology Cancer

Avelumab (anti-PD-L1) a fully human IgG1 anti-PD-L1 monoclonal antibody (mAb) with potential antibody-dependent cell-mediated cytotoxicity (ADCC). Avelumab (anti-PD-L1) enhances ADCC on several cancer cell lines expressing PD-L1. Avelumab (anti-PD-L1) can be used for the study of chordoma .
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6
6 Cited Publications
Art. -Nr.: HY-P99340
CAS. Nr.: 2423014-07-5
Synonyms: VIR 7831; GSK-4182136

Target:  

SARS-CoV

Forschungsgebiete:  

Infection Cancer

Sotrovimab (VIR 7831) is a human IgG1κ pan-sarbecovirus monoclonal antibody (mAb), neutralizes SARS-CoV-2, SARS-CoV-1, and multiple other sarbecoviruses. Sotrovimab is developed based on S309, exhibits a long half-life and great bioavailability in the respiratory mucosa. Sotrovimab could result in immune-mediated viral clearance and prevent progression of Covid-19 early in the course of disease .
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3
3 Cited Publications
Art. -Nr.: HY-P99006
CAS. Nr.: 931402-35-6
Synonyms: MORab-009

Target:  

Mesothelin

Forschungsgebiete:  

Cancer

Amatuximab (MORab-009) is a chimeric, humanized IgG1/k MAb that targets the cell surface mesothelin (MSLN). Mesothelin is a glycosylphosphatidyl inositol (GPI)-anchored membrane glycoprotein, which is present in a restricted set of normal adult tissues such as the mesothelium .
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1
1 Cited Publications
Art. -Nr.: HY-P990121

Target:  

Interleukin Related

Forschungsgebiete:  

Inflammation/Immunology Cancer

Anti-Mouse IL-4 Antibody (11B11) is an anti-mouse IL-4 IgG1 monoclonal antibody. Anti-Mouse IL-4 Antibody (11B11) can inhibit Th2 cell differentiation by blocking the IL-4 signaling pathway. Anti-Mouse IL-4 Antibody (11B11) can significantly reduce fibrosis combined with anti-IL13 mAb. Anti-Mouse IL-4 Antibody (11B11) can be used for researches on cancer and inflammation conditions such as colorectal cancer and prostatitis .
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1
1 Cited Publications
Art. -Nr.: HY-P99291
CAS. Nr.: 892553-42-3
Synonyms: LM609; MEDI-522

Target:  

Integrin Apoptosis Akt

Forschungsgebiete:  

Cancer

Etaracizumab (LM 609) is an αvβ3 integrin IgG mAb. Etaracizumab is developed to target αvβ3+ cancer cells via NK cell-mediated cytotoxicity. Etaracizumab sterically hinders access of large ligands to the RGD-binding pocket, without obstructing it. Etaracizumab decreases p-Akt in vitro. Etaracizumab can decrease cancer proliferation and invasion. Etaracizumab induces tumor cell apoptosis, and inhibition ofαvβ3-mediated cell adhesion, endothelial cell migration and osteoclast-mediated bone resorption. Etaracizumab can be studied in anti-tumor research against cancers such as ovarian cancer, metastatic melanoma as well as advanced solid tumors. Recommend Isotype Control: Human IgG1 kappa, Isotype Control (HY-P99001) .
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1
1 Cited Publications
Art. -Nr.: HY-P99435
CAS. Nr.: 2509447-07-6
Synonyms: BRII-196

Target:  

SARS-CoV

Forschungsgebiete:  

Infection

Amubarvimab (BRII-196) is a human IgG1 mAb that bind to non-competing epitopes on the receptor binding domain (RBD) of spike protein, with a KD of 5.88 nM. Amubarvimab can effectively neutralize SARS-CoV-2 variants .
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1
1 Cited Publications
Art. -Nr.: HY-P9801
Synonyms: SARS-CoV-2 (2019-nCoV) Spike RBD Antibody

Target:  

SARS-CoV

Forschungsgebiete:  

Infection

Anti-Spike-RBD mAb is a CHO cell derived human monoclonal IgG1 antibody. Blocking the interaction of Spike protein and ACE2. Anti-Spike-RBD mAb is a potential therapeutic approach for SARS-CoV-2 treatment .
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Art. -Nr.: HY-P991471

Target:  

Interleukin Related

Forschungsgebiete:  

Inflammation/Immunology

GB-0895 is a human monoclonal antibody (mAb) targeting TSLP. GB-0895 can be used in Asthma research. Recommended isotype control: Human IgG1 kappa, Isotype Control (HY-P99001) .
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Art. -Nr.: HY-P99384
CAS. Nr.: 1312305-12-6
Synonyms: B-701; MFGR-1877S; RG-7444

Target:  

FGFR

Forschungsgebiete:  

Cancer

Vofatamab (B-701) is an anti-FGFR3 monoclonal antibody (mAb). Vofatamab blocks activation of both the wildtype and genetically activated receptor. Vofatamab can be used in the research of metastatic urothelial carcinoma (mUC). Recommend Isotype Controls: Human IgG1 kappa, Isotype Control (HY-P99001) .
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Art. -Nr.: HY-P99480
CAS. Nr.: 1918149-01-5
Synonyms: M7824; MSB0011359C

Target:  

TGF-β Receptor

Forschungsgebiete:  

Cancer

Bintrafusp alfa (M 7824) is a first-in-class bifunctional fusion protein composed of the extracellular domain of TGF-βRII fused to a human IgG1 mAb blocking programmed cell death ligand. Bintrafusp alfa can be used for the research of cancer .
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Art. -Nr.: HY-P99829
CAS. Nr.: 1869937-48-3
Synonyms: PF-06647020; ABBV-647; h6M24-vc0101

Forschungsgebiete:  

Cancer

Cofetuzumab pelidotin (PF-06647020) is a PTK7-targeting ADC comprising a humanized anti-PTK7 mAb (hu6M024, IgG1) joined to an auristatin microtubule inhibitor payload, auristatin-0101 (Aur0101; HY-12522), by a cleavable valine-citrulline (vc)-based linker. Cofetuzumab pelidotin has a DAR of 4. Cofetuzumab pelidotin binds to cell-surface PTK7 with an EC50 of 1153 pM by flow cytometry. Cofetuzumab pelidotin has the potential for solid tumors research .
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Art. -Nr.: HY-P991442
Synonyms: TAK-920

Target:  

TREM receptor

Forschungsgebiete:  

Neurological Disease

DNL-919 (TAK-920) is a human IgG1 monoclonal antibody (mAb) targeting TREM-2. DNL-919 can be used in Alzheimer's disease research. Recommended isotype control: Human IgG1 kappa, Isotype Control (HY-P99001) .
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Art. -Nr.: HY-P99157
CAS. Nr.: 1895083-75-6
Synonyms: mAb 8H9
Target:  

CD276/B7-H3

Forschungsgebiete:  

Neurological Disease Cancer

Omburtamab (Mab 8H9) is a mouse monoclonal immunoglobulin G1 (IgG1) antibody targeting B7-H3. Omburtamab specifically binds to the glycoprotein antigen B7-H3, which is widely expressed on the surface of tumor cells. As a targeting carrier for recombinant toxins, it delivers PE38 to inhibit cellular protein synthesis and induce cytotoxicity in antigen-expressing cancer cells. Omburtamab can be used in research related to glioma, breast cancer, osteosarcoma and neuroblastoma .
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Art. -Nr.: HY-P99181
CAS. Nr.: 2451856-97-4
Synonyms: CPI-006

Target:  

CD73

Forschungsgebiete:  

Infection Inflammation/Immunology Cancer

Mupadolimab (CPI-006) is an IgG1κ humanized FcγR binding-deficient anti-CD73 monoclonal antibody (mAb) that activates CD73 POS B cells .
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Art. -Nr.: HY-P99621
CAS. Nr.: 2467411-25-0
Synonyms: NPC-21; EV2038

Target:  

CMV

Forschungsgebiete:  

Infection

Fiztasovimab (NPC-21; EV2038) is a fully human IgG1λ mAb against human cytomegalovirus (hCMV). Fiztasovimab acts neutralizing activity by binding to the antigenic domain 1 of glycoprotein B on hCMV envelope. Fiztasovimab inhibits cell-to-cell transmission of hCMV .
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Art. -Nr.: HY-P991422
Synonyms: DS9231; TS-23; CSL-301

Target:  

PAI-1

Stromab (DS9231) is a human IgG1 monoclonal antibody (mAb) targeting Serpin F2. Recommended isotype control: Human IgG1 kappa, Isotype Control (HY-P99001) .
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Art. -Nr.: HY-P99822
CAS. Nr.: 2361290-85-7
Synonyms: SHR-1209

Target:  

PCSK9

Forschungsgebiete:  

Metabolic Disease

Recaticimab (SHR-1209) is a humanized IgG1 mAb that selectively targets PCSK9. Recaticimab reduces low-density lipoprotein cholesterol (LDL-C), non-high-density lipoprotein cholesterol (non-HDL-C), apolipoprotein B (ApoB), triglyceride (TG), and lipoprotein(a) levels. Recaticimab can be used for hyperlipidemia research .
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Art. -Nr.: HY-P991180

Target:  

TNF Receptor

Forschungsgebiete:  

Cancer

TRX-518 is a humanized agylcosyl IgG1 anti-GITR mAb, , and is a GITR agonist. TRX-518 binds to the extracellular domain of human GITR, abrogates Treg-mediated suppression. TRX-518 increases effector T cell activation and pro-inflammatory cytokine production, reduces circulating and intratumor Treg frequencies. TRX-518 destabilizes Treg phenotype via Foxp3 downregulation and T-bet upregulation. TRX-518 can be used for the research of solid tumors[1][2][3].
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Art. -Nr.: HY-P991424

Forschungsgebiete:  

Inflammation/Immunology

GSK2618960 is a human monoclonal antibody (mAb) targeting IL-7Ra/CD127. GSK2618960 inhibits IL-7-induced STAT5 phosphorylation. GSK2618960 enhances CD4 T cell proliferation response and increases CD83, CD86, and CD209 expression in PBMCs. GSK2618960 can be used for the research of autoimmune and allergic inflammatory diseases. Recommended isotype control: Human IgG1 kappa, Isotype Control (HY-P99001) .
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