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Amatuximab

(Synonyms: MORab-009)
3 Cited Publications
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Based on 3 publication(s) in Google Scholar

Amatuximab (MORab-009) is a chimeric, humanized IgG1/k MAb that targets the cell surface mesothelin (MSLN). Mesothelin is a glycosylphosphatidyl inositol (GPI)-anchored membrane glycoprotein, which is present in a restricted set of normal adult tissues such as the mesothelium.

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  • Reinheit: 99.90%
  • CAS. Nr.: 931402-35-6
  • Molecular Weight:144.363 kDa
  • Speicherung:

    Please store the product under the recommended conditions in the Certificate of Analysis.

  • Experimental Validation Results for Amatuximab
  • Experimental Validation Results for Amatuximab
  • Experimental Validation Results for Amatuximab
  • Amatuximab Chemical Structure
  • Experimental Validation Results for Amatuximab
  • Experimental Validation Results for Amatuximab
  • Experimental Validation Results for Amatuximab
  • Amatuximab Chemical Structure
    Amatuximab Chemical Structure
CAS. Nr.: 931402-35-6
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Assay Types
  • 1/16

    Human IgG1 kappa

  • 1/16

    Flow cytometric analysis of 1X106 Hela cells with Amatuximab (HY-P99006, red). Cells were fixed with 4% paraformaldehyde. Then stained with the primary antibody at 1/200 dilution for an hour at 4℃. Alexa Fluor 488-conjugated AffiniPure Goat Anti-Human IgG H&L (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG1 kappa Isotype Control (HY-P99001, blue) was used as the isotype control, cells without incubation with primary antibody were used as the unlabeled control (black).

  • 1/16

    Loaded Amatuximab on AHC2 biosensor, can bind Mesothelin Protein, Human (303a.a, HEK293, His, HY-P70148) with an affinity constant of 6.469E-10 M as determined in BLI assay.

  • Amatuximab Chemical Structure
    1/16
  • Amatuximab
  • Flow cytometric analysis of 1X106 Hela cells with Amatuximab (HY-P99006, red). Cells were fixed with 4% paraformaldehyde. Then stained with the primary antibody at 1/200 dilution for an hour at 4℃. Alexa Fluor 488-conjugated AffiniPure Goat Anti-Human IgG H&L (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG1 kappa Isotype Control (HY-P99001, blue) was used as the isotype control, cells without incubation with primary antibody were used as the unlabeled control (black).
  • Loaded Amatuximab on AHC2 biosensor, can bind Mesothelin Protein, Human (303a.a, HEK293, His, HY-P70148) with an affinity constant of 6.469E-10 M as determined in BLI assay.