LSP1 - lymphocyte specific protein 1 Gene

Also Known as WP34; pp52

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 4046

About LSP1

Cytogenetic location: 11p15.5 Genomic coordinates (GRCh38): 11:1,853,084-1,892,263 (from NCBI)

This gene has 18 transcripts (splice variants), 1 gene allele, 204 orthologues and 1 paralogue. Broad expression in spleen (RPKM 60.6), appendix (RPKM 43.3) and 19 other tissues.

Summary

This gene encodes an intracellular F-actin binding protein. The protein is expressed in lymphocytes, neutrophils, macrophages, and endothelium and may regulate neutrophil motility, adhesion to fibrinogen matrix proteins, and transendothelial migration. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

LSP1 Products (6)

mRNA Protein Name
NM_001013253.2 NP_001013271.1 lymphocyte-specific protein 1 isoform 2
NM_001013254.1 NP_001013272.1 lymphocyte-specific protein 1 isoform 2
NM_001013255.1 NP_001013273.1 lymphocyte-specific protein 1 isoform 2
NM_001242932.2 NP_001229861.1 lymphocyte-specific protein 1 isoform 3
NM_001289005.2 NP_001275934.1 lymphocyte-specific protein 1 isoform 2
NM_002339.3 NP_002330.1 lymphocyte-specific protein 1 isoform 1

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
35156780 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

LSP1 Protein Structure

Caldesmon

Caldesmon: Caldesmon (191 - 300)

  • 0
  • 100
  • 200
  • 300
  • 339 a.a.
Protein Preferred Names Protein Names

lymphocyte-specific protein 1

  • 47 kDa actin binding protein

LSP1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
LSP1 P33241 CFTR Homo sapiens P13569
Ub Reconstruction
35156780
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant LSP1 Proteins

Cat. No. Product Name Accession Purity
HY-P75916 LSP1 Protein, Human (HEK293, His) P33241-1 (M1-P339) ≥ 95%, as determined by reducing SDS-PAGE.

LSP1 Antibodies

Cat. No. Product Name Application Reactivity
HY-P81344 LSP1 Antibody (YA1089) IHC-P Human
HY-P81344A LSP1 Antibody (YA1089)(PBS only) IHC-P Human

Related Diseases

Diseases Alias
Neutrophil Actin Dysfunction

  • NAD
Pyometritis
Breast Cancer

  • Breast Carcinoma

  • Male Breast Cancer

  • Breast Cancer, Familial

  • Malignant Neoplasm Of Breast

  • Breast Cancer, Susceptibility To

  • Breast Cancer, Early-Onset

  • Malignant Tumor Of Breast

  • Carcinoma Of Male Breast

  • Breast Cancer, Invasive Ductal

  • Breast Cancer, Protection Against

  • Breast Cancer, Somatic

  • Breast Cancer, Male

  • Breast Cancer, Lobular, Somatic

  • Breast Tumor

  • Mammary Cancer

  • Mammary Tumor

  • Malignant Neoplasm Of Male Breast

  • Mammary Carcinoma

  • Male Breast Carcinoma

  • Familial Cancer Of Breast

  • Invasive Ductal Breast Carcinoma

  • Breast Cancer Susceptibility

  • Breast Cancer, Male, Susceptibility To

  • Breast Cancer, Early-Onset, Susceptibility To

  • Malignant Tumor Of The Breast

  • Mammary Neoplasm

  • Primary Breast Cancer

  • Neoplasm Of Male Breast

  • Carcinoma Of Breast

  • Breast Cancer In Men

  • Familial Breast Cancer

  • Cancer Of Breast

  • BC

  • Breast Cancer Familial

  • Breast Cancer Familial Male

  • Breast Cancer, Familial Male

  • Breast Male Carcinoma

  • Breast Neoplasms

  • Breast Neoplasms, Male

  • Mammary Tumors

  • Mammary Carcinomas

  • Cancer, Breast

  • Cancer, Breast, Susceptibility

  • Invasive Breast Ductal Carcinoma

  • Breast Neoplasm

  • Susceptibility To Breast Cancer

  • Mammary Neoplasms

  • Animal Mammary Neoplasms

  • Primary Malignant Neoplasm Of Breast

  • Infiltrating Ductal Carcinoma Of Breast

  • Infiltrating Duct Carcinoma Of Unspecified Site

  • Infiltrating Ductular Carcinoma Of Unspecified Site

  • Invasive Breast Carcinoma Of No Special Type

  • Microinvasive Carcinoma Of Breast

  • Carcinoma With Apocrine Differentiation
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS07864 LSP1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-11041 LSP1-2111 Agonist / Unkown
HY-RS19613 Lsp1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26108 Lsp1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris LSP1 VGNC VGNC:42849
Rattus norvegicus LSP1 RGD RGD:1306133
Mus musculus LSP1 MGD MGI:96832
Bos taurus LSP1 VGNC VGNC:31063
Felis catus LSP1 VGNC VGNC:68096
Macaca mulatta LSP1 VGNC VGNC:101299
Others LSP1 NCBI