PEA15 - proliferation and apoptosis adaptor protein 15 Gene

Also Known as PED; MAT1; HMAT1; MAT1H; PEA-15; HUMMAT1H; PED-PEA15; PED/PEA15

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 8682

About PEA15

Cytogenetic location: 1q23.2 Genomic coordinates (GRCh38): 1:160,205,384-160,215,372 (from NCBI)

This gene has 4 transcripts (splice variants) and 196 orthologues. Broad expression in brain (RPKM 413.0), fat (RPKM 91.8) and 18 other tissues.

Summary

This gene encodes a death effector domain-containing protein that functions as a negative regulator of Apoptosis. The encoded protein is an endogenous substrate for protein kinase C. This protein is also overexpressed in type 2 diabetes mellitus, where it may contribute to Insulin resistance in glucose uptake. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]

PEA15 Products (4)

mRNA	Protein	Name
NM_001297576.2	NP_001284505.1	astrocytic phosphoprotein PEA-15 isoform a
NM_001297577.2	NP_001284506.1	astrocytic phosphoprotein PEA-15 isoform b
NM_001297578.2	NP_001284507.1	astrocytic phosphoprotein PEA-15 isoform c
NM_003768.5	NP_003759.1	astrocytic phosphoprotein PEA-15 isoform b

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Références	Source
enables protein binding	IPI IPI: Inferred from physical interaction	10442631	GOA

Biological Process GO Annotation	Evidence	Références	Source
involved in negative regulation of D-glucose import	IDA IDA: Inferred from direct assay	9670003	GOA
involved in negative regulation of extrinsic apoptotic signaling pathway via death domain receptors	IDA IDA: Inferred from direct assay	10442631	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PEA15 Protein Structure

DED

0
100
130 a.a.

Protein Preferred Names	Protein Names
astrocytic phosphoprotein PEA-15	15 kDa phosphoprotein enriched in astrocytes

PEA15 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Références
Intra	PEA15	Q15121	MAPK3	Homo sapiens	P27361	Y2H	21900206
Intra	PEA15	Q15121	MAPK3	Homo sapiens	P27361	Y2H Array	32296183
Intra	PEA15	Q15121	MAPK3	Homo sapiens	P27361	Y2H Prey Pooling	32296183
Intra	PEA15	Q15121	MAPK3	Homo sapiens	P27361	Anti Tag CoIP	33961781
Intra	PEA15	Q15121	MAPK1	Homo sapiens	P28482	Anti Tag CoIP	33961781
Intra	PEA15	Q15121	MAPK1	Homo sapiens	P28482	Anti Tag CoIP	17255949

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant PEA15 Proteins

Cat. No.	Nom du produit	Accession	Pureté
HY-P71195	PEA15 Protein, Human	Q15121 ( M1-A130)	≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases	Alias
Type 2 Diabetes Mellitus	Insulin Resistance NIDDM Type 2 Diabetes Diabetes Mellitus, Non-Insulin-Dependent T2D Noninsulin-Dependent Diabetes Mellitus Diabetes Mellitus, Type Ii Maturity-Onset Diabetes Insulin Resistance, Severe, Digenic Diabetes Mellitus, Type 2 Diabetes Mellitus, Noninsulin-Dependent Diabetes Mellitus, Noninsulin-Dependent, Association With Diabetes Mellitus, Noninsulin-Dependent, Late Onset Hypertension, Insulin Resistance-Related, Susceptibility To Insulin Resistance, Susceptibility To Non-Insulin-Dependent Diabetes Mellitus Type Ii Diabetes Mellitus Adult-Onset Diabetes Mellitus Maturity-Onset Diabetes Mellitus Diabetes Mellitus Type 2 Type Ii Diabetes Type 2 Diabetes Mellitus, Susceptibility To Diabetes, Type 2 Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To Diabetes Mellitus, Type 2, Susceptibility To Diabetes Mellitus, Noninsulin-Dependent, 2 Diabetes Mellitus, Type Ii, Susceptibility To Hypertension, Insulin Resistance-Related Adult-Onset Diabetes Aodm Diabetes Mellitus, Adult-Onset Diabetes Mellitus Type Ii Diabetes Mellitus Type 2, Susceptibility To Diabetes, Type Ii, Susceptibility To Diabetes Type 2 Diabetes Mellitus Adult Onset Diabetes Maturity Onset Diabetes Nonketotic Diabetes Non-Insulin Dependent Diabetes Mellitus T2dm - [Type 2 Diabetes Mellitus] Niddm - [Non Insulin Dependent Diabetes Mellitus] Dm2 Dm Type Ii Diabetic Type 2 Insulin Requiring Type 2 Diabetes Noninsulin Dependent Diabetes Non-Insulin-Dependent Diabetes Mellitus Without Complications Diabetes Due To Insulin Secretory Defect Diabetes Mellitus Due To Insulin Secretory Defect Non-Insulin-Dependent Diabetes Of The Young Senile Diabetes Nonketotic Hyperglycaemia Stable Diabetes
Diabetes Mellitus	Diabetes
Alopecia-Mental Retardation Syndrome 1	APMR1 Alopecia-Intellectual Disability Syndrome 1 Amr Syndrome Alopecia-Intellectual Disability Syndrome Amr Syndrome 1 Alopecia With Severe Intellectual Deficit Apmr Alopecia Intellectual Disbility Syndrome 1 Perniola-Krajewska-Carnevale Syndrome Alopecia - Intellectual Disability Syndrome Alopecia With Mental Retardation Syndrome 1 Perniola Krajewska Carnevale Syndrome
Breast Cancer	Breast Carcinoma Male Breast Cancer Breast Cancer, Familial Malignant Neoplasm Of Breast Breast Cancer, Susceptibility To Breast Cancer, Early-Onset Malignant Tumor Of Breast Carcinoma Of Male Breast Breast Cancer, Invasive Ductal Breast Cancer, Protection Against Breast Cancer, Somatic Breast Cancer, Male Breast Cancer, Lobular, Somatic Breast Tumor Mammary Cancer Mammary Tumor Malignant Neoplasm Of Male Breast Mammary Carcinoma Male Breast Carcinoma Familial Cancer Of Breast Invasive Ductal Breast Carcinoma Breast Cancer Susceptibility Breast Cancer, Male, Susceptibility To Breast Cancer, Early-Onset, Susceptibility To Malignant Tumor Of The Breast Mammary Neoplasm Primary Breast Cancer Neoplasm Of Male Breast Carcinoma Of Breast Breast Cancer In Men Familial Breast Cancer Cancer Of Breast BC Breast Cancer Familial Breast Cancer Familial Male Breast Cancer, Familial Male Breast Male Carcinoma Breast Neoplasms Breast Neoplasms, Male Mammary Tumors Mammary Carcinomas Cancer, Breast Cancer, Breast, Susceptibility Invasive Breast Ductal Carcinoma Breast Neoplasm Susceptibility To Breast Cancer Mammary Neoplasms Animal Mammary Neoplasms Primary Malignant Neoplasm Of Breast Infiltrating Ductal Carcinoma Of Breast Infiltrating Duct Carcinoma Of Unspecified Site Infiltrating Ductular Carcinoma Of Unspecified Site Invasive Breast Carcinoma Of No Special Type Microinvasive Carcinoma Of Breast Carcinoma With Apocrine Differentiation

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Nom du produit	Effect	Pureté	Rare Diseases
HY-20685S2	Palmitoylethanolamide-d5	Inhibitor	99.80%	Unkown
HY-RS10309	PEA15 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25323	Pea15 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	PEA15	VGNC	VGNC:44406
Rattus norvegicus	PEA15	RGD	RGD:1306055
Mus musculus	PEA15	MGD	MGI:104799
Bos taurus	PEA15	VGNC	VGNC:32732
Macaca mulatta	PEA15	VGNC	VGNC:100030
Felis catus	PEA15	VGNC	VGNC:97551
Others	PEA15	NCBI