GY1-22
GY1-22 is an inhibitor of DNAJA1-mutP53R175H interacting pocket. GY1-22 can be used for the research of cancer.
Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.
- CAS No.: 326903-84-8
- Formule: C23H20N4OS
- Masse moléculaire:400.50
-
Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Activité biologique
-
Chemical Information
- Pureté et documentation
- Références
-
Help & FAQs
Activité biologique
DNAJA1-mutP53R175H interacting pocket[1]
GY1-22 (0-50 μM; 24 h) reduces mutp53 protein expression in mouse pancreatic cancer P03 and human colon cancer LS123 cells. GY1-22 inhibits cyclin D1 expression and induces wtp53-activated Waf1p21 expression in mutp53-driven P03 cells[1].
GY1-22 loses the ability to degrade mutp53R175H after mutation of critical sites at the interface of the DNAJA1–mutp53R175H complex[1].
GY1-22 (0-100 μM; 24 h) shows a dose-dependent effect on inhibiting cell growth and low cytotoxicity in mutp53-driven P03 pancreatic cancer cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Cell Line:Mouse mutp53-driven P03 pancreatic cancer cells and human colon cancer LS123 cells
-
Concentration:0, 1, 10, 25 and 50 μM
-
Incubation Time:24 h
-
Result:Reduced mutp53 protein expression in both cells.
Exhibited a dose-dependent effect on inhibition of mutp53 and cyclin D1 expression but induction of wtp53-activated Waf1p21 expression tested in P03 cells.
-
Cell Line:Mouse mutp53-driven P03 pancreatic cancer cells
-
Concentration:0, 25, 50, 75 and 100 μM
-
Incubation Time:24 h
-
Result:Showed a dose-dependent effect on inhibiting cell growth with IC50 of 28 μM and low cytotoxicity (cell viability).
GY1-22 (1 mg/kg; i.p.; daily for 2 weeks) inhibits mutp53-driven P03 pancreatic cancer cell growth in mice[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Animal Model:C57BL/6J mice implanted with P03 cells[1]
-
Dosage:1 mg/kg
-
Administration:IP, daily for 2 weeks
-
Result:Showed a significant inhibition of in vivo tumor growth, which was comparable with P03 DNAJA1 knockout line.
Chemical Information
-
CAS No. 326903-84-8
-
Masse moléculaire 400.50
-
Formule C23H20N4OS
-
SMILES
C1(N=C(SCC2=NC3=C(N2)C=CC=C3)N4CCOC5=CC=CC=C5)=C4C=CC=C1
-
Livraison
Room temperature in continental US; may vary elsewhere.
-
Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
GY1-22 Related Classifications
HY-149911 Related Classifications
Powered by Bioz