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Cat. No.: HY-162627

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LDHA-IN-6

LDHA-IN-6 (compound 6) is an oral bioactive inhibitor of lactate dehydrogenase-A (LDHA), with the IC₅₀ of 46 nM. LDHA-IN-6 has antitumor activity.

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CAS No.: 3043790-18-4
Formule: C₂₃H₂₀F₃N₃O₄
Masse moléculaire:459.42

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (267 KB)

LDHA-IN-6 Chemical Structure

CAS No.: 3043790-18-4

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- Cellular Effect
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

LDHA-IN-6 (compound 6) is an oral bioactive inhibitor of lactate dehydrogenase-A (LDHA), with the IC₅₀ of 46 nM. LDHA-IN-6 has antitumor activity^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
MIA PaCa-2	IC₅₀	25.552 μM Compound: 6	Antiproliferative activity against human MIA PaCa-2 cells incubated for 48 hrs by Hoechst 33342 and SYTOX green staining based confocal imaging analysis Antiproliferative activity against human MIA PaCa-2 cells incubated for 48 hrs by Hoechst 33342 and SYTOX green staining based confocal imaging analysis	[PMID: 38925013]
PANC-1	IC₅₀	23.944 μM Compound: 6	Antiproliferative activity against human PANC-1 cells incubated for 48 hrs by Hoechst 33342 and SYTOX green staining based confocal imaging analysis Antiproliferative activity against human PANC-1 cells incubated for 48 hrs by Hoechst 33342 and SYTOX green staining based confocal imaging analysis	[PMID: 38925013]

Chemical Information

CAS No. 3043790-18-4
Masse moléculaire 459.42
Formule C₂₃H₂₀F₃N₃O₄
SMILES

O=C(OC)C(C1=CC=C(C(F)(F)F)C=C1)CC(NC2=CC=C(C(C3=NC=CN3C)=O)C=C2)=O
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (267 KB)
SDS (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Horrick Sharma, et al. Synthesis and biological characterization of an orally bioavailable lactate dehydrogenase-A inhibitor against pancreatic cancer. Eur J Med Chem. 2024 Jun 17:275:116598. [Content Brief]

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

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MOQ

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100 mg

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