pDI
pDI is a peptide. pDI inhibits MDM2-p53 and MDMX-p53 interactions with IC50s of 10 and 100 nM respectively. pDI can be used in the research of colorectal cancer.
Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.
- CAS No.: 1443628-44-1
- Formule: C71H99N17O19
- Masse moléculaire:1494.65
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
IC50: 10 nM (MDM2-p53); 100 nM (MDMX-p53)[2]
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS No. 1443628-44-1
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Masse moléculaire 1494.65
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Formule C71H99N17O19
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Sequence
Leu-Thr-Phe-Glu-His-Tyr-Trp-Ala-Gln-Leu-Thr-Ser-NH2
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Sequence Shortening
LTFEHYWAQLTS-NH2
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
[1]. Xu L, et al. Design, Synthesis, and Biological Evaluation of Lysine-Stapled Peptide Inhibitors of p53-MDM2/MDMX Interactions with Potent Antitumor Activity In Vivo. J Med Chem. 2024 Oct 10;67(19):17893-17904. [Content Brief]
[2]. Hu B, et al. Efficient p53 activation and apoptosis by simultaneous disruption of binding to MDM2 and MDMX. Cancer Res. 2007 Sep 15;67(18):8810-7. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
pDI Related Classifications
HY-P11256 Related Classifications
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