PRDX1-IN-3
Based on 1 Customer Validation
PRDX1-IN-3 (compound 19-048) is a PRDX1 covalent inhibitor with anti-colorectal cancer activity. PRDX1-IN-3 can effectively inhibit the proliferation of colorectal cancer cells, and its antitumor effect on nude mice with colorectal cancer carrying PRDX1 gene knockout is significantly reduced. PRDX1-IN-3 also upregulates the downstream genes of the p53 signaling pathway to exert an anticancer effect.
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- Pureté : 99.52%
- CAS No.: 2566976-46-1
- Formule: C33H46N2O5
- Masse moléculaire:550.73
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Stockage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
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Solvant et solubilité
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
Description
IC50 & Target
PRDX1[1]
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HCT-116 | IC50 |
0.28 μM
Compound: 24; 19-048
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Antiproliferative activity against human HCT-116 cells assessed as inhibition of cell growth
Antiproliferative activity against human HCT-116 cells assessed as inhibition of cell growth
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[PMID: 38142509] |
| HCT-116 | IC50 |
0.8 μM
Compound: 3; 19-048
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Inhibition of cell viability in human HCT-116 cells incubated for 72 hrs by Cell Titer Glo assay
Inhibition of cell viability in human HCT-116 cells incubated for 72 hrs by Cell Titer Glo assay
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[PMID: 38679872] |
| SW-620 | IC50 |
0.28 μM
Compound: 24; 19-048
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Antiproliferative activity against human SW620 cells assessed as inhibition of cell growth
Antiproliferative activity against human SW620 cells assessed as inhibition of cell growth
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[PMID: 38142509] |
| SW-620 | IC50 |
0.33 μM
Compound: 3; 19-048
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Inhibition of cell viability in human SW620 cells incubated for 72 hrs by Cell Titer Glo assay
Inhibition of cell viability in human SW620 cells incubated for 72 hrs by Cell Titer Glo assay
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[PMID: 38679872] |
Chemical Information
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CAS No. 2566976-46-1
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Appearance Solid
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Masse moléculaire 550.73
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Formule C33H46N2O5
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Color orange
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SMILES
C[C@@]12[C@]([C@@]3([H])[C@@](CC1)(CC[C@](C)(C3)NC(N[C@@H](C)C(OC)=O)=O)C)(CC[C@@]4(C2=CC=C5C4=CC(C(O)=C5C)=O)C)C
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvant et solubilité
In Vitro:
DMSO : 12.5 mg/mL (22.70 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureté et documentation
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Fiche technique (272 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Instruction de manipulation (2659 KB)
Références
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.8158 mL | 9.0789 mL | 18.1577 mL | 45.3943 mL |
| 5 mM | 0.3632 mL | 1.8158 mL | 3.6315 mL | 9.0789 mL | |
| 10 mM | 0.1816 mL | 0.9079 mL | 1.8158 mL | 4.5394 mL | |
| 15 mM | 0.1211 mL | 0.6053 mL | 1.2105 mL | 3.0263 mL | |
| 20 mM | 0.0908 mL | 0.4539 mL | 0.9079 mL | 2.2697 mL |
PRDX1-IN-3 Related Classifications
HY-171272 Related Classifications
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