Przewaquinone B
Przewaquinone B is an abietane-type diterpene quinone (tanshinone) and a diterpenoid compound. Przewaquinone B can be isolated from the rhizomes of Salvia miltiorrhiza Bunge, the roots of Salvia przewarskii, and the roots of Salvia constanea. Przewaquinone B exhibits antitumor activity against cervical cancer and promyelocytic leukemia. Przewaquinone B can be used in research related to cervical cancer and promyelocytic leukemia.
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- CAS No.: 76829-01-1
- Formule: C18H12O4
- Masse moléculaire:292.29
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Protocole
- Pureté et documentation
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Help & FAQs
Activité biologique
Description
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| KB | IC50 |
3.22 μM
Compound: 6
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Antiproliferative activity against human KB cells after 72 hrs by sulforhodamine B assay
Antiproliferative activity against human KB cells after 72 hrs by sulforhodamine B assay
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[PMID: 29294282] |
| HeLa | IC50 |
19.0 μM
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Cytotoxicity against human cervical cancer HeLa cells.
Cytotoxicity against human cervical cancer HeLa cells.
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27032190 |
| HL-60 | IC50 |
3.0 μM
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Cytotoxicity against human promyelocytic leukemia HL-60 cells.
Cytotoxicity against human promyelocytic leukemia HL-60 cells.
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27032190 |
In Vitro
Przewaquinone B exhibits weak cytotoxicity against HeLa cells (IC50 = 19.0 μM) and significant cytotoxicity against HL-60 cells (IC50 = 3.0 μM)[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
Chemical Information
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CAS No. 76829-01-1
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Masse moléculaire 292.29
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Formule C18H12O4
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SMILES
O=C1C(C2=C(C3=C1C(C=CC=C4C)=C4C=C3)OC=C2CO)=O
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Structure Classification
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Initial Source
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocole
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Subcutaneous Cell-Line-Derived Xenograft
Subcutaneous cell-line-derived xenograft (CDX) models are established by implanting cultured human cancer cell lines into immunodeficient mice, where the injected cells form localized tumors that can be monitored in vivo as a measure of tumorigenic potential, growth kinetics, and treatment response. These models are widely used in oncology research because they allow reproducible tumor formation and enable comparative assessment of tumor growth between different cell lines or genetic manipulations in a controlled in vivo microenvironment. Subcutaneous implantation of cancer cells in immunodeficient mice is a standard approach for evaluating tumor growth behavior and therapeutic response across multiple cancer types, including prostate, esophageal, pancreatic, and colon cancer models.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Przewaquinone B Related Classifications
HY-N13355 Related Classifications
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