Quoromycin
Quoromycin is an orally active SmcR inhibitor with a Kd of 0.697 μM for Vibrio vulnificus SmcR. Quoromycin binds directly to SmcR, reduces its DNA-binding affinity, and inhibits the quorum sensing signaling pathway. Quoromycin is applicable to the research of Vibrio vulnificus infection.
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- CAS No.: 205514-29-0
- Formule: C12H8N2O2S
- Masse moléculaire:244.27
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
Quoromycin (1-50 μM) dose-dependently inhibits the binding of Vibrio vulnificus SmcR to the vvpE promoter DNA without altering SmcR protein levels[1].
Quoromycin (1-50 μM; 25 h) dose-dependently reduces elastase activity in Vibrio vulnificus without inhibiting bacterial growth[1].
Quoromycin (1-50 μM; 12 h) inhibits Vibrio vulnificus vvpE promoter activity with an IC50 of 322 nM[1].
Quoromycin (20 μM) reduces vvpE transcript levels, elastase activity, and exoprotease activity in wild-type Vibrio vulnificus to levels similar to an smcR mutant strain[1].
Quoromycin (1-100 μM; 3 h at 37 °C) dose-dependently reduces Vibrio vulnificus-induced cytotoxicity and bacterial adhesion to INT-407 human intestinal epithelial cells[1].
Quoromycin (20 μM) inhibits quorum sensing in Vibrio harveyi and reduces proteolytic activity in Vibrio anguillarum without inhibiting bacterial growth of either species[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:INT-407 human intestinal epithelial cells infected with Vibrio vulnificus
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Concentration:1, 10, 25, 50, 100 μM
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Incubation Time:3 h at 37 °C
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Result:Reduced Vibrio vulnificus-induced cytotoxicity in INT-407 cells in a dose-dependent manner, with 100 μM quoromycin returning LDH levels to non-infected control levels.
Reduced Vibrio vulnificus adhesion to INT-407 cells in a dose-dependent manner, with 50 μM quoromycin reducing adherent CFUs by half compared to controls.
Quoromycin (122 μg/kg; i.g.; single simultaneous dose with infection) significantly reduces V. vulnificus colonization in mouse small intestine, liver, and spleen, and prevents infection-associated tissue damage[1].
Quoromycin (30-122 μg/kg; i.g.; single dose) shows no acute in vivo cytotoxicity in healthy ICR female mice, with 100% 24-hour survival[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:ICR mice (female, 7-week-old, pathogen-free)[1]
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Dosage:61 μg/kg; 122 μg/kg
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Administration:i.g.; single simultaneous dose with infection
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Result:Conferred 60% 24-hour survival at 122 μg/kg (vs 10% in untreated controls).
Significantly prolonged survival at 61 μg/kg relative to untreated infected mice.
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Animal Model:ICR mice (female, pathogen-free)[1]
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Dosage:122 μg/kg
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Administration:i.g.; single simultaneous dose with infection
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Result:Reduced small intestine colonization index to ~-3 log.
Reduced liver colonization index to ~-4.5 log.
Reduced spleen colonization index to ~-5 log.
Prevented edema, hemorrhage, vasodilation, necrosis, and intestinal inflammation/swelling observed in untreated infected mice.
Chemical Information
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CAS No. 205514-29-0
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Masse moléculaire 244.27
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Formule C12H8N2O2S
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SMILES
N#CC1=CN=C(C=C1)S(=O)(=O)C=2C=CC=CC2
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Quoromycin Related Classifications
HY-W788542 Related Classifications
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